Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat

International Journal of Experimental Pathology
J Rojas-CastañedaMarcela Arteaga-Silva

Abstract

Neonatal exposure to monosodium glutamate (MSG) induces circadian disorders in several physiological and behavioural processes regulated by the suprachiasmatic nucleus (SCN). The objective of this study was to evaluate the effects of neonatal exposure to MSG on locomotor activity, and on morphology, cellular density and expression of proteins, as evaluated by optical density (OD), of vasopressin (VP)-, vasoactive intestinal polypeptide (VIP)- and glial fibrillary acidic protein (GFAP)-immunoreactive cells in the SCN. Male Wistar rats were used: the MSG group was subcutaneously treated from 3 to 10 days of age with 3.5 mg/g/day. Locomotor activity was evaluated at 90 days of age using 'open-field' test, and the brains were processed for immunohistochemical studies. MSG exposure induced a significant decrease in locomotor activity. VP- and VIP-immunoreactive neuronal densities showed a significant decrease, while the somatic OD showed an increase. Major axes and somatic area were significantly increased in VIP neurons. The cellular and optical densities of GFAP-immunoreactive sections of SCN were significantly increased. These results demonstrated that newborn exposure to MSG induced morphological alterations in SCN cells, an alt...Continue Reading

References

Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·K ShinoharaK Honma
Aug 1, 1994·Neuroscience Research·S T Inouye, S Shibata
Apr 18, 1994·Brain Research·R A ProsserJ D Miller
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·M DubovickyD Jezova
Oct 6, 1998·Neurochemistry International·C Beas-ZárateA Feria-Velasco
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Aug 1, 1957·A.M.A. Archives of Ophthalmology·D R LUCAS, J P NEWHOUSE
Jun 9, 2005·Neurotoxicology and Teratology·Zdenek HlinákIvan Krejcí
Jan 27, 2006·The Anatomical Record. Part B, the New Anatomist·Domenico RibattiMarco Artico
Dec 5, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jia-Da LiQun-Yong Zhou
Sep 8, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mónica E Ureña-GuerreroCarlos Beas-Zárate
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Jan 12, 2011·Progress in Neurobiology·J Middeldorp, E M Hol
Feb 18, 2011·International Journal of Experimental Pathology·Julio César Rojas-CastañedaCamilo Ríos
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fritz KobeEvgeni Ponimaskin
Dec 12, 2012·Reproductive Biology and Endocrinology : RB&E·Glaura Sa FernandesWilma G Kempinas
May 28, 2013·Current Opinion in Neurobiology·Clifford B Saper
May 7, 2014·The European Journal of Neuroscience·Rae Silver, Lance J Kriegsfeld
Jun 5, 2014·The European Journal of Neuroscience·Holly C CormierMartin R Ralph
Feb 24, 2015·Journal of Pharmacological Sciences·Linda NguyenRae R Matsumoto

❮ Previous
Next ❯

Citations

Jan 1, 2021·Analytical Cellular Pathology (Amsterdam)·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda
Mar 20, 2021·Psychopharmacology·Karline C RodriguesCristiane Luchese
Jun 29, 2021·Journal of Chemical Neuroanatomy·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.