Neonatal exposure to staphylococcal superantigen improves induction of oral tolerance in a mouse model of airway allergy

European Journal of Immunology
Anna LönnqvistCarola Rask

Abstract

The hygiene hypothesis suggests that lack of microbial stimulation in early infancy may lead to allergy, but it has been difficult to identify particular protective microbial exposures. We have observed that infants colonised in the first week(s) of life with Staphylococcus aureus have lower risk of developing food allergy. As many S. aureus strains produce superantigens with T-cell stimulating properties, we here investigate whether neonatal mucosal exposure to superantigen could influence the capacity to develop oral tolerance and reduce sensitisation and allergy. BALB/c mice were exposed to staphylococcal enterotoxin A (SEA) as neonates and fed with OVA as adults, prior to sensitisation and i.n. OVA challenge. Our results show that SEA pre-treated mice are more efficiently tolerised by OVA feeding, as shown by lower lung-cell infiltration and antigen-specific IgE response in the SEA pre-treated mice, compared with sham-treated mice. This was not due to deletion or anergy of lymphocytes by SEA treatment, because the SEA pre-treated mice that were fed with PBS showed similar inflammatory response as the sham-treated PBS-fed mice. Our results suggest that strong T-cell activation in infancy conditions the mucosal immune system ...Continue Reading

References

Jun 1, 1991·Acta paediatrica Scandinavica·I AdlerberthL A Hanson
Oct 1, 1990·The Journal of Experimental Medicine·B L RellahanL A Matis
Feb 1, 1989·Immunological Reviews·C A JanewayS Buxser
May 1, 1984·Infection and Immunity·J T BeeryM S Bergdoll
Jan 1, 1995·Life Sciences·M A Blackman, D L Woodland
Feb 13, 1996·Annals of the New York Academy of Sciences·A M MowatP Garside
Apr 21, 1997·The Journal of Experimental Medicine·A R HamadJ W Kappler
Feb 25, 1999·Epidemiology and Infection·I AdlerberthA E Wold
Oct 10, 2001·European Journal of Immunology·M KarlssonE Telemo
Feb 28, 2002·Annual Review of Immunology·Pierre GuermonprezSebastian Amigorena
Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna GrundströmFredrik Ivars
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pascal FeunouMichel Y Braun
Feb 10, 2004·Journal of Clinical Microbiology·Erika LindbergAgnes E Wold
Jul 13, 2005·European Journal of Immunology·Fernando G ChirdoAllan McI Mowat
Nov 30, 2005·Immunology·Sofia OstmanEsbjörn Telemo
Aug 10, 2006·European Journal of Immunology·Sofia OstmanEsbjörn Telemo
Jan 11, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A-C LundellA Rudin
Jul 25, 2008·European Journal of Immunology·Ennio De GregorioRino Rappuoli

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Citations

Aug 17, 2011·The Journal of Infectious Diseases·Forough L NowrouzianGerard Lina
Apr 15, 2011·Immunological Reviews·Howard L WeinerHenry Wu
Sep 21, 2010·Current Opinion in Immunology·Valérie Verhasselt
Dec 21, 2013·Immunological Investigations·Nicolae MironVictor Cristea

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