Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Reproduction : the Official Journal of the Society for the Study of Fertility
Oscar E RiveraE H Luque

Abstract

Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens, which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs. Thus, we evaluated the ovarian response to exogenous ovine FSH (oFSH) administered from postnatal day 30 (PND30) to PND32 in female lambs previously exposed to low doses of DES or BPA (BPA50: 50 μg/kg per day, BPA0.5: 0.5 μg/kg per day) from PND1 to PND14. We determined: i) follicular growth, ii) circulating levels of 17β-estradiol (E2), iii) steroid receptors (estrogen receptor alpha, estrogen receptor beta, and androgen receptor (AR)) and atresia, and iv) mRNA expression levels of the ovarian bone morphogenetic protein (BMPs) system (BMP6, BMP15, BMPR1B, and GDF9) and FSH receptor (FSHR). Lambs neonatally exposed to DES or BPA showed an impaired ovarian response to oFSH with a lower number of follicles ≥2 mm in diameter together with a lower number of atretic follicles and no increase in E2 serum levels in response to oFSH treatment. In addition, AR induction by oFSH was disrupted in granulosa and theca cells of lambs exposed to DES or BPA. An increase in GDF9 mRNA expression levels was observed in oFSH...Continue Reading

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Citations

Dec 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Clarisa SantamaríaRodriguez A Horacio
May 26, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Xing DuQifa Li
Jul 16, 2016·Fertility and Sterility·Ayelet Ziv-Gal, Jodi A Flaws
Oct 25, 2016·Toxicology Letters·Dennis R MüllerPatrick Diel
Jul 22, 2016·Reproduction, Fertility, and Development·K D SinclairC M Dwyer
Aug 4, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Paola I IngaramoEnrique H Luque
Aug 20, 2018·The Journal of Endocrinology·Marlise Guerrero SchimpfJorgelina Varayoud
May 12, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Jan NevoralMilena Králíčková
Mar 17, 2020·Reproductive Biology and Endocrinology : RB&E·Claudia PivonelloRosario Pivonello
Jul 13, 2020·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Taiming YanZhi He
Apr 25, 2021·European Journal of Pediatrics·Sarah ZulkifliNoor Shafina Mohd Nor

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