PMID: 12770688May 29, 2003Paper

Neonatal expression of progesterone receptor isoforms in the cerebellar Purkinje cell in rats

Neuroscience Letters
Hirotaka SakamotoKazuyoshi Tsutsui

Abstract

The cerebellar Purkinje cell (PC) is a typical site for neurosteroid formation. Progesterone synthesized de novo in developing PCs participates in the promotion of dendritic growth, spinogenesis and synaptogenesis in this neuron and such organizing actions may contribute to the formation of the cerebellar neuronal circuit during rat neonatal life. Progesterone receptors (PR) occur as two isoforms (PR-A and PR-B) derived from a single gene. To clarify the mode of organizing actions of progesterone, therefore, we examined the expression of these PR isoforms in the rat cerebellum during development. Western immunoblot analysis revealed that both PR isoforms were expressed highly in the cerebellum during neonatal life and the expression decreased thereafter. PR-like immunoreactivity was localized primarily in PCs in the neonatal cerebellum. Thus, progesterone may act directly on PCs via PR isoforms to promote its dendritic growth, spinogenesis and synaptogenesis.

Citations

Aug 18, 2009·Cerebral Cortex·Vaishali Jahagirdar, Christine K Wagner
May 22, 2010·Expert Opinion on Investigational Drugs·Donald G Stein, David W Wright
Sep 11, 2007·Brain Research Reviews·Donald G Stein
Nov 23, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Kazuyoshi Tsutsui
Aug 21, 2008·Developmental Neurobiology·Princy S QuadrosChristine K Wagner
Jun 16, 2004·Neuroscience Research·Kazuyoshi TsutsuiKazuyoshi Ukena
May 17, 2014·Frontiers in Cellular Neuroscience·Kazuyoshi Tsutsui, Shogo Haraguchi
May 18, 2004·Anatomia, histologia, embryologia·M Yarim, N Kabakci
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michael SchumacherAlejandro F De Nicola
Jun 16, 2004·Neuroscience Letters·Hanako ShikimiKazuyoshi Tsutsui
Aug 22, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lisa WesselCarsten Theiss
Sep 10, 2003·Endocrinology·Hirotaka SakamotoKazuyoshi Tsutsui
Mar 1, 2008·Endocrinology·Kazuyoshi Tsutsui
Mar 13, 2020·FASEB BioAdvances·Kazuyoshi Tsutsui, Shogo Haraguchi
Jan 20, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Dalila Nj MancinoLaura I Garay

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