Neonatal Extracorporeal Membrane Oxygenation: Update on Management Strategies and Long-Term Outcomes

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses
Yee Hui MokIra M Cheifetz

Abstract

Extracorporeal membrane oxygenation (ECMO) can be deployed to support patients with severe cardiorespiratory failure unresponsive to conventional medical interventions. Neonatal trials have demonstrated that ECMO is an effective treatment of severe respiratory failure, with acceptable cognitive and functional outcomes. Technological advances in ECMO have resulted in improved safety and accessibility, contributing to decreased morbidity and improved survival of increasingly complex patients requiring ECMO support. This review aims to describe the innovations in ECMO technology and management in the neonatal population in the last decade. The long-term outcomes of neonatal patients requiring ECMO support will be discussed. Relevant clinical trials from MEDLINE and the Cochrane Library were identified. The following key words were used: ECMO, infant, neonate, and outcomes. Challenges still remain in supporting the premature and/or low-birth-weight infant with severe respiratory failure, as well as infants with congenital diaphragmatic hernia. Neonatal ECMO survivors can present with neurodevelopmental and respiratory problems, which become more prominent with time. While newer technologies have led to fewer neonates with respirato...Continue Reading

References

May 1, 1978·American Journal of Surgery·J H Gibbon
Jul 1, 1989·ASAIO Transactions·H L AndersonR H Barlett
Jul 15, 1993·Annals of Internal Medicine·P Brill-EdwardsJ Hirsh
Jan 1, 1990·Perfusion·P L AllisonJ B Zwischenberger
Aug 12, 1999·Journal of Pediatric Surgery·S B ShewT Jaksic
Apr 12, 2001·Lancet·C C BennettUNKNOWN UK Collaborative ECMO Trial Group
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michael S D Agus, Tom Jaksic
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Manon N HanekampDick Tibboel
Sep 15, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·K KhambekarH C Pandya
Dec 20, 2005·Thrombosis Research·Vera IgnjatovicPaul Monagle
Apr 26, 2006·Pediatrics·Helena McNallyUNKNOWN UK Collaborative ECMO Trial Group
Jun 2, 2006·The Journal of Pediatrics·Paola J FlimanRobin H Steinhorn
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Craig A NankervisLeif D Nelin
Jul 27, 2007·Pediatric Pulmonology·Carina M MajaesicCharlene M T Robertson
Oct 3, 2008·Thrombosis Research·Fiona NewallPaul Monagle
Oct 3, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·A KarimovaA Goldman
Nov 15, 2008·Seminars in Perinatology·Michael A Portman
Mar 28, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Meredith AllenDuncan Macrae
Apr 4, 2009·Critical Care : the Official Journal of the Critical Care Forum·Maria W G Nijhuis-van der SandenLouis A A Kollée
May 20, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cindy S BarrettRavi R Thiagarajan
Mar 17, 2010·Intensive Care Medicine·Pierre TissièresPeter C Rimensberger
May 11, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alaina K KippsJane W Newburger
May 15, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Tom JaksicUNKNOWN American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
Jun 29, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ward HofhuisPeter J F M Merkus
Jul 6, 2010·Current Opinion in Hematology·Mark R LooneyMichael A Matthay
Oct 26, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·Melissa MurrayPhilippe Friedlich
Nov 23, 2010·American Journal of Clinical Pathology·Wassia A KhajaJun Teruya
Dec 22, 2010·The Annals of Thoracic Surgery·Joshua W SalvinRavi R Thiagarajan
May 5, 2011·The European Respiratory Journal·M H M van der Cammen-van ZijpH Ijsselstijn
Aug 9, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jonathan ByrnesRichard Fiser

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Citations

Oct 4, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Eiji HirakawaHisanori Minakami
Dec 18, 2016·Pediatric Surgery International·Darya Kadir, Helene Engstrand Lilja
Dec 6, 2018·Annals of Clinical Biochemistry·Ramona C Dolscheid-PommerichFlorian Kipfmueller
Feb 6, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Maryam Vasheghani FarahaniSayed Mahdi Marashi
Oct 16, 2019·Frontiers in Pediatrics·Francesco MacchiniGiacomo Cavallaro

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