Neonatal factors predictive for respiratory and gastro-intestinal morbidity after esophageal atresia repair

Pediatrics and Neonatology
Maissa RayyanNathalie Rommel

Abstract

Esophageal atresia is a major congenital foregut anomaly. Affected patients often suffer from respiratory and gastro-intestinal morbidity. The objective of this study is to identify possible neonatal predictive factors contributing to a long-term complicated clinical course in patients after repair of esophageal atresia. A total of 93 patients born between 1993 and 2013, with esophageal atresia and surviving the neonatal period were included in this retrospective study. A complicated clinical course was defined as the occurrence of ≥1 of these complications: severe gastro-esophageal reflux, esophageal stricture requiring dilatations, need for tube feeding for >100 days, severe tracheomalacia, severe chronic respiratory disease and death. We used linear models with a binomial distribution to determine risk factors for gastro-intestinal or respiratory complicated evolution and a backward stepwise elimination procedure to reduce models until only significant variables remained in the model. Multinomial logistic regression was used to assess risk factors for different evolutions of complication. Model parameter estimates were used to calculate odds ratios for significant risk factors. Fifty-seven patients (61%) had a complicated cl...Continue Reading

Citations

Apr 8, 2020·World Journal of Gastroenterology : WJG·Isabelle TrainiUsha Krishnan
Jul 7, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Mustafa O OztanAbdullah Yildiz
Aug 21, 2021·Pediatrics·Stéphanie LejeuneFrédéric Gottrand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
R ShahU Krishnan
European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
M Montgomery, B Frenckner
© 2022 Meta ULC. All rights reserved