PMID: 7525113Jul 15, 1994Paper

Neonatal handling alters serotonin (5-HT) turnover and 5-HT2 receptor binding in selected brain regions: relationship to the handling effect on glucocorticoid receptor expression

Brain Research. Developmental Brain Research
J W SmytheM J Meaney

Abstract

Neonatal handling permanently alters hypothalamic-pituitary-adrenal responses to stress. This effect is, in part, mediated by a handling-induced increase in forebrain glucocorticoid receptor gene expression. The effect of postnatal handling on glucocorticoid receptor expression appears to be mediated by an increase in serotonin (5-HT) activity, acting via a 5-HT2 receptor with a high affinity for 5-HT (i.e. the 5-HT2H receptor). In the present study we examined the nature of the effects of handling on the relevant 5-HT systems. We found that: (1) handling increases 5-HT turnover in regions of the neonatal rat brain where glucocorticoid receptor expression is altered (i.e. the hippocampus and frontal cortex), but not in regions where glucocorticoid receptor expression in unaffected (e.g. hypothalamus and amygdala); (2) handling has no long-term effects on hippocampal or frontal cortex 5-HT turnover, and is actually associated with a decrease in 5-HT concentrations; and (3) handling does not alter 5-HT2 receptor density in the hippocampus or frontal cortex in neonates (although there are surprising effects on 5-HT2 receptor density in the frontal cortex of adult animals). Taken together these data provide further evidence for the...Continue Reading

References

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Citations

Feb 27, 2004·Physiology & Behavior·P P SilveiraC Dalmaz
Aug 7, 1998·Biological Psychiatry·T R Insel, J T Winslow
Apr 16, 1998·European Journal of Pharmacology·S R ThorntonF L Smith
Jun 24, 2003·Physiology & Behavior·Frances ConnanJanet Treasure
Dec 18, 2001·Brain Research. Developmental Brain Research·P KehoeC M McCormick
Dec 14, 2002·Brain Research. Developmental Brain Research·Patricia LaplanteMichael J Meaney
Oct 12, 1999·Neurochemistry International·J IrazustaL Casis
Dec 12, 2001·Molecular and Cellular Endocrinology·J R Seckl
Dec 26, 2001·Brain Research Bulletin·P M Whitaker-Azmitia
Jan 21, 2000·Neurotoxicology and Teratology·P ClausingB Opitz
Oct 25, 2011·Development and Psychopathology·Brittany R Howell, Mar M Sanchez
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Nov 13, 2013·Neuroscience and Biobehavioral Reviews·Nicole StrüberGerhard Roth
Nov 18, 2010·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Benoit Labonte, Gustavo Turecki
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Marcus H Andrews, Stephen G Matthews
Jun 28, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Undurti N Das
Dec 16, 2010·Journal of Neuropathology and Experimental Neurology·Julie A WixeyKathryn M Buller
Jul 2, 2010·Hormones and Behavior·Anjanette Harris, Jonathan Seckl
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Feb 17, 2009·Seminars in Fetal & Neonatal Medicine·Ian C G Weaver
Dec 23, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Annie DuchesneRon M Sullivan

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