Neonatal heart transplantation

Annals of Cardiothoracic Surgery
Mohan John, Leonard L Bailey

Abstract

Neonatal heart transplantation was developed and established in the 1980's as a durable modality of therapy for complex-uncorrectable heart disease. Patients transplanted in the neonatal period have experienced unparalleled long-term survival, better than for any other form of solid-organ transplantation. However, the limited availability of neonatal and young infant donors has restricted the indications and applicability of heart transplantation among newborns in the current era. Indications for heart transplantation include congenital heart disease not amenable to other forms of surgical palliation, and cardiomyopathy, including some primary tumors. Use of ABO-incompatible transplants, and organs with prolonged cold ischemic time or marginal function have all been associated with good outcomes in infants. These extended strategies to increase the donor pool may also someday include donation after determination of circulatory death and the use of anencephalic donors. The operative techniques for donors and recipients of neonatal heart transplantation are unique and have been well-described. Immunosuppression protocols for neonates need not include induction and are largely steroid-free. Newborn and young infant transplant reci...Continue Reading

Citations

Aug 7, 2018·Current Opinion in Organ Transplantation·Miguel I DoranteBohdan Pomahac
Dec 12, 2018·Xenotransplantation·Jeffrey L PlattMarilia Cascalho
Dec 6, 2019·The Journal of Physiology·Martin G FraschDino A Giussani
Aug 28, 2020·Pediatric Transplantation·Mohamed BikhetHayato Iwase
Feb 19, 2021·Archives of Disease in Childhood·Gunnar WikHenrik Holmstrøm
Mar 14, 2021·The Journal of Thoracic and Cardiovascular Surgery·Douglas M Overbey, Andrew J Lodge
May 8, 2021·European Journal of Pediatrics·Marieke DonnéJoseph Panzer
May 4, 2021·Current Opinion in Organ Transplantation·John D Cleveland, S Ram Kumar
May 20, 2021·Current Opinion in Organ Transplantation·John D Cleveland, S Ram Kumar
Jun 9, 2021·The Journal of Thoracic and Cardiovascular Surgery·Yihan LinT Konrad Rajab
Aug 6, 2021·Transplant Immunology·M SchweigerUNKNOWN Swiss Transplant Cohort Study
Jun 9, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andrew BentallSimon Ball

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