Neonatal hemochromatosis

Journal of Clinical and Experimental Hepatology
Amy G Feldman, Peter F Whitington

Abstract

Neonatal hemochromatosis is a clinical condition in which severe liver disease in the newborn is accompanied by extrahepatic siderosis. Gestational alloimmune liver disease (GALD) has been established as the cause of fetal liver injury resulting in nearly all cases of NH. In GALD, a women is exposed to a fetal antigen that she does not recognize as "self" and subsequently begins to produce IgG antibodies that are directed against fetal hepatocytes. These antibodies bind to fetal liver antigen and activate the terminal complement cascade resulting in hepatocyte injury and death. GALD can cause congenital cirrhosis or acute liver failure with and without iron overload and siderosis. Practitioners should consider GALD in cases of fetal demise, stillbirth, and neonatal acute liver failure. Identification of infants with GALD is important as treatment is available and effective for subsequent pregnancies.

Citations

Jul 31, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazuki HatayamaHirokazu Tsukahara
Dec 28, 2019·Journal of Pediatric Gastroenterology and Nutrition·Hendrik S FischerChristoph Bührer
Mar 15, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Burcu GüvenMurat Çakır
Oct 26, 2016·Obstetrics and Gynecology·Hannah B AnastasioKarin J Blakemore
Mar 3, 2017·Case Reports in Pediatrics·Carolina Roos Mariano da RochaSandra Maria Gonçalves Vieira
Dec 30, 2017·Journal of Pediatric Gastroenterology and Nutrition·Khaled AleneziGovind B Chavhan
Aug 20, 2019·Pediatric Hematology and Oncology·Larisa BroglieJulie-An Talano
Feb 29, 2020·Nature Reviews. Gastroenterology & Hepatology·Patrick J McKiernan, Robert H Squires
Nov 14, 2018·Pediatric Annals·Ranjani Ananth
Jan 24, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Seema AlamDinesh Rawat
Jul 27, 2017·Expert Review of Gastroenterology & Hepatology·Andrea Catzola, Pietro Vajro
Jan 1, 2019·Fetal and Pediatric Pathology·Suvradeep MitraUma Saikia
Dec 21, 2018·Neonatal Network : NN·Oksana KaskoAmy Jnah
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Priyanka M ChaudhuriSuchandra Mukherjee
Apr 29, 2016·Journal of Paediatrics and Child Health·Naomi E ClarkeSheryle Rogerson
Feb 7, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Hao WuKalyani Patel
Jan 14, 2017·Pediatric Research·Estelle DubrucSophie Collardeau-Frachon
Dec 7, 2017·World Journal of Gastroenterology : WJG·Ivan IvanovskiPetar Ivanovski
Nov 5, 2020·Indian Journal of Pediatrics·M G KartheekaArvind Shenoi
Mar 13, 2021·Pediatric Radiology·Govind B ChavhanChristopher Tomlinson
Mar 30, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A Di GiorgioL D'Antiga
Nov 23, 2018·Journal of Gynecology Obstetrics and Human Reproduction·Clémentine SciardMona Massoud
Nov 11, 2021·Journal of Paediatrics and Child Health·Eleanor LastDavid Moore
Aug 2, 2017·Pediatrics·Diana Montoya-Williams, Meredith Mowitz
Feb 27, 2021·Pediatrics·Jaime Flores-TorresAmarilis Sanchez-Valle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.