Neonatal high pressure hydrocephalus is associated with elevation of pro-inflammatory cytokines IL-18 and IFNgamma in cerebrospinal fluid.

Cerebrospinal Fluid Research
Deborah A SivalAxel Heep

Abstract

In human neonatal high pressure hydrocephalus (HPHC), diffuse white matter injury and gliosis predispose to poor neuro-developmental outcome. The underlying mechanism for diffuse white matter damage in neonatal HPHC is still unclear. Analogous to inflammatory white matter damage after neonatal hypoxemia/ischemia, we hypothesized that pro-inflammatory cytokines could be involved in neonatal HPHC. If so, early anti-inflammatory therapy could ameliorate white matter damage in HPHC, before irreversible apoptosis has occurred. In HPHC and control neonates, we therefore aimed to compare cerebrospinal fluid (CSF) concentrations of IL18, IFNgamma and sFasL (interleukin 18, interferon gamma and apoptosis marker soluble-Fas ligand, respectively). In neonatal HPHC (n = 30) and controls (n = 15), we compared CSF concentrations of IL18, IFNgamma and sFasL using sandwich ELISA. HPHC was grouped according to etiology: spina bifida aperta (n = 20), aqueduct stenosis (n = 4), and fetal intra-cerebral haemorrhage (n = 6). Neonatal control CSF was derived from otherwise healthy neonates (n = 15), who underwent lumbar puncture for exclusion of meningitis. In all three HPHC groups, CSF IL18 concentrations were significantly higher than control valu...Continue Reading

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Citations

Aug 19, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramin EskandariJames P McAllister
Jul 13, 2012·Fluids and Barriers of the CNS·Satish KrishnamurthyKenneth A Jenrow
Aug 12, 2009·Pediatric Research·Wolfgang BueterAlan Leviton
Aug 11, 2015·Lancet·Kristopher T KahleBenjamin C Warf
Aug 18, 2010·Experimental Neurology·Kelley E DerenJames P McAllister
Feb 18, 2017·PloS One·David D LimbrickDiego M Morales
May 27, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Maria Florencia VarelaMarc Oria
Jul 16, 2021·Journal of Applied Physiology·Jeff F Dunn, Albert M Isaacs
Apr 19, 2019·Developmental Neuroscience·Marcelo Volpon SantosRicardo Santos de Oliveira

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