Neonatal hippocampal Tat injections: developmental effects on prepulse inhibition (PPI) of the auditory startle response

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Sylvia FittingCharles F Mactutus

Abstract

The current estimate of children (<15 years) living with HIV and AIDS is 2.2 million. The major source of infection occurs through vertical transmission of the virus from mother to child during delivery [UNAIDS/WHO, 2005. AIDS Epidemic Update. UNAIDS, Geneva]. Recent studies have shown that timing of HIV-1 infection might be related to the onset and rate of progression of CNS disease. The effects of HIV on the brain are thought to be mediated indirectly through the viral toxins Tat and gp120. This study characterized developmental effects on PPI following intrahippocampal administration of Tat. On postnatal day (P)1, one male and one female pup from each of eight Sprague-Dawley litters were bilaterally injected with 50 microg Tat or saline (1 microl volume). Animals were tested for PPI of the auditory startle response (ASR) (ISIs of 0, 8, 40, 80, 120, and 4000 ms, six trial blocks, Latin-square design) on days 30, 60 and 90. Tat altered PPI and the pattern of alterations was different for males and females. For males, a leftward shift was evident in the ISI for maximal inhibition of the response on day 30 and on day 60 (chi(2)(1)=4.7, p< or =.03, and chi(2)(1)=5.3, p< or =.02, respectively), but not on day 90. For females, Tat ...Continue Reading

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Citations

May 22, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Landhing M MoranCharles F Mactutus
Nov 28, 2013·Behavioural Pharmacology·Brook L HenryUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Jun 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Sylvia FittingCharles F Mactutus
Oct 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Landhing M MoranCharles F Mactutus
Nov 26, 2015·Neurobiology of Disease·Gretchen N NeighTanja Jovanovic
Mar 4, 2015·Brain, Behavior, and Immunity·Michael VigoritoSulie L Chang
Sep 10, 2014·Behavioural Brain Research·Nathanael J YatesJennifer Rodger
Dec 15, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ryan T LacySteven B Harrod
Aug 20, 2016·Journal of Neurovirology·Kristen A McLaurinCharles F Mactutus
Jun 23, 2006·Pharmacology, Biochemistry, and Behavior·Sylvia FittingCharles F Mactutus
Oct 5, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kristen A McLaurinCharles F Mactutus
Feb 18, 2017·International Journal of Molecular Sciences·Antonio Victor Campos CoelhoSergio Crovella
Sep 7, 2016·Scientific Reports·Kristen A McLaurinCharles F Mactutus
Nov 8, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sylvia FittingCharles F Mactutus
Sep 30, 2015·Developmental Psychobiology·Landhing M MoranCharles F Mactutus
Jan 4, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kristen A McLaurinCharles F Mactutus
Jan 5, 2019·Journal of Neurovirology·Kristen A McLaurinCharles F Mactutus

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