Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT).

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Libby M MorimotoCatherine Metayer

Abstract

Background: Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. In contrast to TGCT among infants, it is hypothesized that TGCT in adolescents and young men is the result of sex steroid hormone imbalance during early fetal development. However, little is known about the neonatal period when abrupt hormonal changes occur, and direct supporting evidence is scarce due to the difficulties in obtaining prediagnostic specimens.Methods: We conducted a population-based case-control study examining hormone levels at birth among 91 infants (0-4 years) and 276 adolescents (15-19 years) diagnosed with TGCT, and 344 matched controls. Estrogen and androgen levels were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS) from archived newborn dried blood spots. Logistic regression models were used to estimate the association between each hormone level and TGCT risk.Results: Higher levels of androstenedione were associated with increased TGCT risk among adolescents [odds ratio (OR): 2.33, 95% confidence interval (CI): 1.37-3.97 for highest vs. lowest quartile; P trend = 0.003] but not among infants (OR: 0.70, 95% CI: 0.28-1.77). A similar pattern was observed for testoste...Continue Reading

References

Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·H K WeirL Sugar
Dec 22, 2000·Genes & Development·S Nef, L F Parada
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Mark P PurdueKatherine A McGlynn
Dec 24, 2005·International Journal of Andrology·Lennart HardellMichael Carlberg
Aug 22, 2007·International Journal of Andrology·Mona N ShahKatherine A McGlynn
May 1, 2008·Journal of the National Cancer Institute·Katherine A McGlynnRalph L Erickson
Dec 19, 2009·Environmental Health Perspectives·Mark P PurdueKatherine A McGlynn
Jul 22, 2011·International Journal of Environmental Research and Public Health·Wissem MnifBenoit Roig
Apr 18, 2012·Nature Reviews. Urology·Katherine A McGlynn, Britton Trabert
Nov 26, 2013·European Urology·Ariana ZnaorFreddie Bray
Jun 3, 2014·The Journal of Clinical Endocrinology and Metabolism·Alicia K HeathDallas R English
Sep 28, 2015·Seminars in Cell & Developmental Biology·Anne JørgensenEwa Rajpert-De Meyts
Dec 15, 2015·Lancet·Ewa Rajpert-De MeytsCarsten Bokemeyer
Feb 20, 2016·Bioanalysis·Anita BoelenMariette T Ackermans
Apr 12, 2016·Andrology·A J Martino-AndradeUNKNOWN TIDES Study Team
Jun 15, 2016·Nature Reviews. Urology·Kevin LitchfieldClare Turnbull
Feb 25, 2017·PloS One·Jessica BurkhamerRichard Clapp

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Citations

Jan 24, 2019·Cellular and Molecular Life Sciences : CMLS·Aalia BatoolYi-Xun Liu
Feb 6, 2020·Journal of the National Cancer Institute·Sumit GuptaMiranda M Fidler-Benaoudia
May 18, 2020·International Journal of Environmental Research and Public Health·Aleksandra FucicVedrana Guszak
Apr 11, 2020·Endocrinology·Penny A F WhileyKate L Loveland
Sep 18, 2020·CA: a Cancer Journal for Clinicians·Kimberly D MillerRebecca L Siegel
Jul 31, 2019·BMC Medicine·UNKNOWN Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group

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