Neonatal hypoxia-ischemia impairs juvenile recognition memory by disrupting the maturation of prefrontal-hippocampal networks

Experimental Neurology
Nina-Kristin DomnickIleana L Hanganu-Opatz

Abstract

High-prevalence/low-severity cognitive deficits represent the life-long burden of a perinatal hypoxic–ischemic (HI) insult. They have been proposed to result from dysmaturation of prelimbic-hippocampal networks, which account for mnemonic and executive performance. Already at neonatal age the communication within these networks is largely reduced after an early HI insult with mild/moderate structural outcome. However, the longlasting consequences of the neonatal network dysfunction remain unknown. Here,we combine MRI and electrophysiology in vivo with behavioral testing to assess the effects of an early HI insult on the structure and function of prelimbic-hippocampal networks and on related cognitive abilities of juvenile rats. Despite the absence of lesions over the prelimbic cortex (PL) and hippocampus (HP), juvenile rats experiencing an early HI have lower performance in item and temporal order recognition memory. These cognitive deficits do not result from delayed somatic development or increased locomotion or anxiety. More likely, abnormal activity patterns and interactions within prelimbic-hippocampal networks account for behavioral impairment. The early HI insult causes power reduction of the fast (12–48 Hz) network acti...Continue Reading

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Citations

Oct 17, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jacqueline SalasThierry A G M Huisman
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