Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes

European Journal of Immunology
Jennifer CzarneskiSusan R Ross

Abstract

Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.

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Citations

Dec 25, 2003·Journal of Virology·Dalia BurzynIsabel Piazzon
Feb 3, 2007·Journal of Virology·Maria Cecilia CourregesSusan R Ross
Sep 1, 2016·American Journal of Veterinary Research·Shohei OgawaRyo Inoue

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