PMID: 7631Aug 1, 1976

Neonatal infection with mouse thymic virus. Differential effects on T cells mediating the graft-versus-host reaction

The Journal of Immunology : Official Journal of the American Association of Immunologists
S S CrossR Asofsky

Abstract

Neonatal infection with mouse thymic virus (TA), a murine herpes virus, produced extensive but temporary necrosis of the thymus which was maximal at 10 to 14 days of age. Studies of precursor and amplifier cells mediating graft-vs-host (GVH) reactivity of thymocytes, spleen cells (SC), and lymph node cells (LNC) of normal and TA-infected mice were made at 4 and 8 weeks of age. Infection with TA resulting in a profound reduction (70 to 80%) in the direct GVH reactivity of thymocytes at both ages; by comparison, the capacity of thymocytes to produce synergy when combined with normal LNC was normal at 8 weeks. Direct GVH reactivity of SC was depressed 90% 4 weeks after infection with TA but returned to near normal at 8 weeks. Direct GVH reactivity of LNC from TA-infected mice was normal at 4 and 8 weeks of age, but amplifier T cell activity in LNC was markedly depressed at 8 wekks. These results demonstrate that TA has highly selective effects upon subpopulations of T cells in thymus and lymph node.

Related Concepts

Graft Vs Host Reaction
Thymic Group Viruses
Herpesviridae Infections
Therapeutic Immunosuppression
Lymph Nodes
Mice, Inbred BALB C
Spleen
T-Lymphocyte
Thymus Gland

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