Neonatal invasive Haemophilus influenzae disease in England and Wales: epidemiology, clinical characteristics, and outcome

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sarah CollinsShamez Ladhani

Abstract

Nontypeable Haemophilus influenzae (NTHi) frequently causes noninvasive upper respiratory tract infections in children but can cause invasive disease, mainly in older adults. An increased burden of invasive NTHi disease in the perinatal period has been reported by a number of studies. Here we describe the epidemiology, clinical characteristics, and outcome of neonatal invasive H. influenzae disease in England and Wales over a 5-year period. Public Health England conducts enhanced national surveillance of invasive H. influenzae disease in England and Wales. Detailed clinical information was obtained for all laboratory-confirmed cases in infants aged ≤31 days during 2009-2013. Overall, 118 live-born neonates had laboratory-confirmed invasive H. influenzae disease: 115 (97%) were NTHi, 2 were serotype f, and 1 was serotype b. NTHi was isolated within 48 hours of birth (early-onset) in 110 of 115 (96%) cases, and 70 of 110 (64%) presented with septicemia. Only 17 mothers (15%) had suspected bacterial infection requiring antibiotics during labor. Few (8/110 [7%]) neonates had comorbidities. The incidence of early-onset NTHi increased exponentially with prematurity, from 0.9 per 100 000 (95% confidence interval [CI], .6-1.4) in term ...Continue Reading

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Citations

Jul 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria GiufrèMarina Cerquetti
Aug 1, 2015·Diagnostic Microbiology and Infectious Disease·Maria GiufrèMarina Cerquetti
May 14, 2016·Human Vaccines & Immunotherapeutics·Marina Cerquetti, Maria Giufrè
Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heidi M SoetersElizabeth C Briere
Nov 17, 2015·The Pediatric Infectious Disease Journal·Sarah CollinsMary P E Slack
Feb 26, 2020·Tropical Medicine and Infectious Disease·Sudipta Roy ChowdhurySuresh Chandran
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Jun 3, 2021·Clinical Microbiology Reviews·M P E SlackM Ulanova

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