Neonatal ketamine exposure causes impairment of long-term synaptic plasticity in the anterior cingulate cortex of rats

Neuroscience
R-R WangJun Chen

Abstract

Ketamine, a dissociative anesthetic most commonly used in many pediatric procedures, has been reported in many animal studies to cause widespread neuroapoptosis in the neonatal brain after exposure in high doses and/or for a prolonged period. This neurodegenerative change occurs most severely in the forebrain including the anterior cingulate cortex (ACC) that is an important brain structure for mediating a variety of cognitive functions. However, it is still unknown whether such apoptotic neurodegeneration early in life would subsequently impair the synaptic plasticity of the ACC later in life. In this study, we performed whole-cell patch-clamp recordings from the ACC brain slices of young adult rats to examine any alterations in long-term synaptic plasticity caused by neonatal ketamine exposure. Ketamine was administered at postnatal day 4-7 (subcutaneous injections, 20mg/kg given six times, once every 2h). At 3-4weeks of age, long-term potentiation (LTP) was induced and recorded by monitoring excitatory postsynaptic currents from ACC slices. We found that the induction of LTP in the ACC was significantly reduced when compared to the control group. The LTP impairment was accompanied by an increase in the α-amino-3-hydroxy-5-me...Continue Reading

References

Feb 14, 1991·Nature·C H DaviesG L Collingridge
Apr 22, 1999·Journal of Pediatric Surgery·N H BoumanF W Hazebroek
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Feb 8, 2003·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vesna Jevtovic-TodorovicDavid F Wozniak
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming-Gao ZhaoMin Zhuo
Apr 4, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laszlo VutskitsJozsef Z Kiss
Aug 12, 2006·Neuropharmacology·Sven BerberichGeorg Köhr
Apr 12, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·William SlikkerCheng Wang
Mar 11, 2008·Trends in Neurosciences·Min Zhuo
Jan 8, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiaoju ZouCheng Wang
May 7, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lai-Hong YanJun Chen
Jul 8, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Xiaoju ZouCheng Wang
Jan 22, 2010·Pediatric Research·Xavier DurrmeyerPeter C Rimensberger
Dec 25, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dian-Shi Wang, Beverley A Orser
Apr 14, 2011·Psychopharmacology·Tomohiro AbekawaTsukasa Koyama
Oct 25, 2011·Cell·Inbal GoshenKarl Deisseroth
Jan 10, 2012·Anesthesiology·Ansgar M BrambrinkJohn W Olney
May 29, 2012·Critical Care Medicine·Chaoxuan DongK J S Anand
Aug 4, 2012·Pediatric Emergency Care·Daniel S TszeJames G Linakis

❮ Previous
Next ❯

Citations

Jan 13, 2017·Anesthesia and Analgesia·Josh D Bell
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Feb 1, 2020·Minerva anestesiologica·Simonetta TesoroEdoardo De Robertis
Feb 29, 2020·Current Neuropharmacology·Xuechao HaoCheng Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.