Neonatal localized neuroblastoma: 52 cases treated from 1990 to 1999

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
M B MichalowskiGroupe Neuroblastome de la Société Française d'Oncologie Pédiatrique

Abstract

Neuroblastoma is the most frequent tumor observed in the newborn. The aim of this study was to review clinical features, treatment and outcome of newborns diagnosed with a localized neuroblastoma. Data from 52 cases treated according to the NBL 90 and 94 protocols between 1990 and 1999 in 18 French centers of pediatric oncology were analyzed. The median age at diagnosis was 12 days (range 0-28) with antenatal detection in 14 patients (27%). Tumor location was abdominal in 40 patients (adrenal in 20 of the 40), thoracic in eight, pelvic in three, and cervical in one. N-myc amplification was observed in one out of 40 evaluable cases. The size of the primary tumor was less than 5 cm in 25 cases, between 5 and 10 cm in 25 and more than 10 cm in two. Dumbbell tumor was observed in seven, of whom five had neurological deficit. One child died from hemorrhage after fine needle biopsy during diagnostic procedure. Primary surgical resection was attempted in 37 infants, of whom two died of surgery related complications and three had nephrectomy. Tumor was deemed as unresectable in 14 patients, and primary chemotherapy was given followed by surgical excision in 12. One of them died a few days after the beginning of chemotherapy. As a whole...Continue Reading

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Citations

Nov 9, 2012·World Journal of Surgery·Denis Andrew CozziCarlo Dominici
Jan 5, 2016·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M KilaniM-N Hattab
Dec 2, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C de Bouyn-IcherO Hartmann
Jun 9, 2009·The Journal of Emergency Medicine·Amy RasmussenBrent King
Feb 16, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Rafael F M RosaPaulo R G Zen
Dec 7, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S DelahayeA Benachi
Apr 25, 2012·Indian Journal of Pediatrics·Sushmita Nitin Bhatnagar, Yogesh Kumar Sarin

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