PMID: 9192418May 1, 1997Paper

Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis

Pediatric Dermatology
Leopoldo BorregoB Hernández

Abstract

Neonatal lupus erythematosus (NLE) is an autoimmune disease whose major findings are skin lesions and congenital heart block. Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases. Mothers of babies with NLE may be asymptomatic initially or may have Sjögren syndrome, lupus erythematosus, overlap syndrome or, uncommonly, leukocytoclastic vasculitis. When evaluating a young woman with a cutaneous leucocytoclastic vasculitis, dermatologists should be aware of the possible presence of antibodies related to NLE. If any patient suffering a disorder related to NLE becomes pregnant, testing for autoantibodies and close obstetric prenatal care with fetal echocardiogram is necessary. In cases of fetal bradycardia, treatment with dexamethasone or betamethasone should be considered, as these drugs are accessible to the fetal circulation.

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Citations

Dec 6, 2008·Clinical Rheumatology·Elaine C JollyKen Farrington
Feb 16, 2006·Actas dermo-sifiliográficas·Yeray PeñateLeopoldo Borrego
Oct 17, 2006·The Journal of Dermatology·Maki Maeda-TanakaSachiko Miyagawa
Sep 24, 1998·British Journal of Obstetrics and Gynaecology·M R Morton
Oct 4, 2000·International Reviews of Immunology·B P Tsao

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