Neonatal lupus

Current Opinion in Rheumatology
J P Buyon

Abstract

Neonatal lupus, albeit rare, affords an excellent opportunity to examine a disease from bedside to bench. Over the past year there have been numerous publications covering clinical aspects and basic research. The timing of heart block is not random; bradycardia is most often identified between 16 and 24 weeks of gestation. Investigations have focused on this apparently vulnerable period and examined the expression of known (SSA/Ro-SSB/La), novel (p57, endogenous retrovirus-3), and cross-reactive (laminin) autoantigens in fetal hearts of varied ages and in adult hearts. Clinical studies are accumulating, but a unique maternal autoantibody profile is yet to be identified. Anti-52-kD responses, measured by enzyme-linked immunosorbent assay and immunoblot, continue to be a nearly universal finding in mothers whose children have neonatal lupus. The presence of anti-U1RNP in the absence of anti-SSA/Ro-SSB/La antibodies occurs only in cases of isolated cutaneous disease and not (to date) in mothers of infants with cardiac manifestations. Immunogenetically, mothers with affected children appear to be more closely related to Sjögren's syndrome than systemic lupus erythematosus. Asymptomatic mothers do not invariably become ill, and if a...Continue Reading

Citations

Sep 21, 2001·Current Rheumatology Reports·L A Lee
Nov 10, 2007·Clinical Reviews in Allergy & Immunology·John G Routsias, Athanasios G Tzioufas
Feb 19, 2002·Clinics in Dermatology·Marcia Ramos-e-SilvaTania Ferreira Cestari
Sep 10, 2003·Current Opinion in Rheumatology·Jill P Buyon, Robert M Clancy
Sep 10, 2003·Journal of Pediatric Gastroenterology and Nutrition·Joanna M BurchLela A Lee
Sep 30, 1999·Current Opinion in Rheumatology·D J Wallace, M Linker-Israeli
Dec 7, 2007·Clinical Pediatrics·Antonio Alberto ZuppaCostantino Romagnoli
Apr 18, 2014·Journal of Immunology Research·Annette Wacker-GussmannJoerg Henes
Jan 3, 2001·Clinics in Dermatology·R I FoxM Stern
Sep 13, 2006·Clinics in Dermatology·Robert I Fox, Alice Y Liu

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