Neonatal medial prefrontal cortex lesion enhances the sensitivity of the mesoaccumbal dopamine system

The European Journal of Neuroscience
Mustapha BennayMichael Koch

Abstract

Neurodevelopmental models of schizophrenia posit that early brain damage leads to dys- or misconnection effects possibly altering synaptic transmission in brain sites distal of the lesion. We tested the hypothesis that neonatal medial prefrontal cortex (mPFC) lesions affect the sensitivity of the mesoaccumbal dopamine (DA) system. Using extracellular single-unit recordings combined with systemic application of the DA agonist apomorphine, followed by the D2 receptor antagonist haloperidol or the D1 receptor antagonist SCH23390, we compared electrophysiological properties of nucleus accumbens core and shell neurons after bilateral excitotoxic lesions of mPFC induced at postnatal day 7 or in adult rats. Whereas animals with adult mPFC lesions showed an altered discharge pattern within the core region, neonatal mPFC lesions altered the discharge pattern within the shell region. Subcutaneous administration of apomorphine (4 mg/kg) reduced accumbal firing rate in 77% of all neurons. Onset and magnitude of apomorphine-induced inhibition of neuronal activity was faster and stronger in rats with neonatal but not adult mPFC lesions in both core and shell regions. Apomorphine-induced inhibition was partially reversed by 0.1 mg/kg haloperi...Continue Reading

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Citations

May 17, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francisca Meyer, Alain Louilot
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miriam Schneider, Michael Koch
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Jan 21, 2011·Journal of Psychiatry & Neuroscience : JPN·Noah L LazarDonald P Cain
Sep 16, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mesbah AlamKerstin Schwabe
Jan 8, 2016·Behavioural Brain Research·Gonzalo FloresAlfonso Diaz
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Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Urs MeyerBenjamin K Yee
Sep 24, 2013·Frontiers in Behavioral Neuroscience·Amy C Reichelt, Jonathan L C Lee

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