Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens and parietal cortex

The European Journal of Neuroscience
Michael T WilliamsCharles V Vorhees

Abstract

Previous studies have demonstrated that rats exposed to methamphetamine (MA) during the neonatal period display deficits in spatial learning and memory. The underlying correlates are unknown; therefore, this study was devised to determine whether neuronal changes occur in the dentate gyrus (DG), nucleus accumbens (NAcc) and cortex of adult rats exposed to 10 mg/kg MA administered four times daily from P11-20 using Golgi-Cox staining [Gibb, R. & Kolb, B. (1998) J. Neurosci. Meth., 79, 1-4]. The DG and NAcc demonstrated a decrease in the number of spines per neuron and the NAcc showed an associated decrease in dendritic length. Selective changes in cortex were observed because increased dendritic length in the parietal cortex occurred with no change in the number of spines, and no differences were noted for either dendritic length or spines in the medial frontal cortex. The data suggest a potential cause for the learning and memory deficits induced by neonatal MA exposure; however, the underlying mechanism that produces these neuronal changes is unknown.

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Citations

Mar 17, 2010·Cellular and Molecular Neurobiology·N HoriD O Carpenter
Sep 1, 2007·Behavioural Pharmacology·Charles V VorheesMichael T Williams
Aug 1, 2014·Neurochemical Research·Monika VrajováRomana Šlamberová
Nov 25, 2014·Toxicology Reports·Michael T WilliamsRussell W Brown
Aug 23, 2011·Neurotoxicology and Teratology·Curtis E GraceCharles V Vorhees
Jun 19, 2008·Neurotoxicology and Teratology·Andrew M SmithWei-Jung A Chen
Feb 22, 2011·Pharmacology, Biochemistry, and Behavior·Brian J PiperJacob Raber
Jul 26, 2011·Schizophrenia Research·Lina OrikabeKiyoto Kasai
Jan 18, 2011·Behavioural Brain Research·Jessica A SiegelJacob Raber
Jun 15, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Sarah A JablonskiCharles V Vorhees
Feb 7, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael D Moenk, Leslie Matuszewich
Feb 12, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael T WilliamsCharles V Vorhees
Jul 30, 2010·Stress : the International Journal on the Biology of Stress·T L SchaeferM T Williams

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