PMID: 8947938Nov 1, 1996Paper

Neonatal neurobehavioral outcome following prenatal exposure to cocaine

Neurotoxicology and Teratology
J C MartinA P Streissguth

Abstract

This substudy of a longitudinal prospective study was designed to assess neurodevelopmental and neurobehavioral performance in newborn infants who were maternally exposed to cocaine and other drugs of abuse or the other drugs without cocaine. Sample selection procedures were designed to permit statistical control for marijuana, alcohol, and tobacco. Cocaine was assessed with both self-report and radioimmunoassay of hair. One hundred ninety-one newborns with a mean age of 43 h were assessed for 35 to 40 min on tests of reflexes, activity level, head-turning preference, tremors, nonnutritive sucking, habituation, and state. The testers were blinded to the baby's drug exposure. Cocaine-exposed newborns were developmentally at risk on the tests administered compared to infants exposed to the other three drugs alone or in some combination. A dose-response effect was found: higher amounts of cocaine were associated with higher neurobehavioral risk scores.

References

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Citations

Mar 3, 2004·Applied Nursing Research : ANR·Anne Marie Higley, Karen H Morin
Jun 1, 2005·Neurotoxicology and Teratology·Fonda Davis EylerIan Tebbett
Aug 8, 2001·Reproductive Toxicology·A AddisG Koren
Mar 25, 1998·Neurotoxicology and Teratology·V P MarkowskiB Weiss
Aug 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·H S BadaP L Maza
Aug 26, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·L L LaGasseJ Liu
Mar 4, 2014·Neurotoxicology and Teratology·Melissa Duncan FalloneCharles R Bauer
Jun 29, 2006·Developmental Psychology·Tracy DennisMichael Lewis
Aug 24, 2000·Seminars in Neonatology : SN·J H Hannigan, D R Armant
Mar 15, 2014·PloS One·Kalindi BakshiHoau-Yan Wang
Dec 12, 2012·PloS One·Roger López-BellidoRaquel E Rodríguez
Mar 1, 2005·Neurotoxicology and Teratology·Beth Nordstrom BaileyVirginia Delaney-Black
Oct 21, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Deborah KartinCara C Ernst
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Toosje Thyssen Van BeverenMelanie J. Spence
Aug 17, 2004·Journal of Developmental and Behavioral Pediatrics : JDBP·Virginia Delaney-BlackRobert J Sokol

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