Neonatal nociceptive somatic stimulation differentially modifies the activity of spinal neurons in rats and results in altered somatic and visceral sensation

The Journal of Physiology
Adrian MirandaJyoti N Sengupta

Abstract

The role ofintramuscular, low pH saline injections during the neonatal period in the development and maintenance of visceral hyperalgesia has not been systematically studied. We aimed to investigate alterations in visceral sensation and neural circuitry that result from noxious stimuli in early life. Neonatal male Sprague-Dawley rats received sterile saline injections of pH 4.0 or 7.4 in the gastrocnemius muscle starting at postnatal day 8. Injections were given unilaterally every other day for 12 days ending on postnatal day 20. A third group received needle prick only on the same shedule as the second group, while a fourth group was left naïve. At 2 months of age, rats underwent assessment of cutaneous and deep somatic sensitivity using von Frey filaments and gastrocnemius muscle pinch, respectively. A visceromotor response (VMR) to graded colorectal distension (CRD; 10-80 mmHg for 30 s with 180 s interstimulus intervals) was recorded. Extracellular single-unit recordings from the thoracolumbar spinal neurons (T13-L1) were performed in adult pH 4.0 injected and naïve controls. There was no difference in the threshold for response to mechanical stimulation of the paw in rats injected with pH 4.0 saline compared to all other gr...Continue Reading

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Citations

Sep 1, 2006·Current Treatment Options in Gastroenterology·Adrian Miranda, Manu Sood
Jan 9, 2009·Nature Clinical Practice. Neurology·Maria Fitzgerald, Suellen M Walker
Aug 27, 2013·Clinics in Perinatology·Suellen M Walker
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Jun 24, 2015·Experimental Neurology·Suellen M WalkerMark L Baccei
May 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A MirandaJ N Sengupta
Oct 5, 2014·European Journal of Pharmacology·Adrian MirandaJyoti N Sengupta
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Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Adrian Miranda
Sep 19, 2019·Paediatric Anaesthesia·Amy FangKen M Brady
Dec 14, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kathryn A HasenstabSudarshan R Jadcherla

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