Abstract
Environmental factors such as diet and bacterial antigens play an important role in the onset of Type 1 diabetes. Different self-antigens are suggested to play a role in the development of diabetes. Antibodies against the 60-kDa heat shock protein 60, which have a high homology to bacterial heat shock protein 65, have been found in the circulation at the onset of diabetes in humans and in pre-diabetic NOD-mice. One of the immunodominant epitopes in autoimmune diabetes is p277, a specific peptide of human heat shock protein 60 corresponding to positions 437-460. In this study we investigated whether neonatal oral administration of DiaPep277 (a synthetic peptide analogue of p277) affected the development of diabetes in the BioBreeding-Diabetes Prone (BB-DP) rat, and whether this could potentiate the effect of a protective hydrolysed casein-diet. BB-DP rats were orally inoculated once per day with placebo or DiaPep277 at days 4, 5, 6 and 7 of life. At the age of 21 days rats were weaned on to a conventional, cereal-based diet or on to the hydrolysed casein-diet. The development of diabetes in animals receiving DiaPep277 in combination with the hydrolysed casein-diet was delayed by 17 days, and a relative reduction of the incidence...Continue Reading
References
Dec 1, 1994·Diabetes·J S PetersenB Michelsen
Apr 1, 1997·Diabetes·F W ScottH Kolb
May 1, 1997·Diabetes·D EliasI R Cohen
Feb 27, 2001·Journal of Autoimmunity·R MaronH L Weiner
Jan 25, 2002·Annals of the New York Academy of Sciences·J W Yoon, H S Jun
Oct 16, 2002·Diabetologia·I R Cohen
Mar 21, 2003·Metabolism: Clinical and Experimental·Jeroen VisserJan Rozing
Citations
Jul 4, 2006·Diabetologia·S BrugmanN A Bos
Apr 28, 2009·Diabetologia·J VisserJ Rozing
Sep 21, 2010·Diabetologia·J T J VisserJ Rozing
May 11, 2012·Diabetologia·C H F HansenA K Hansen
Jun 23, 2009·Annals of the New York Academy of Sciences·Jeroen VisserAlessio Fasano
Jun 11, 2008·Pediatric Diabetes·Nick GiannoukakisMassimo Trucco
Apr 28, 2012·Diabetes/metabolism Research and Reviews·J T J VisserE A F van Tol
May 12, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Basset ElEssawy, Xian C Li
Mar 10, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Changyun HuLi Wen
Apr 29, 2005·Diabetes/metabolism Research and Reviews
May 4, 2007·Diabetes/metabolism Research and Reviews·Paolo Pozzilli
Apr 2, 2005·Nature Reviews. Immunology·Willem van EdenBerent Prakken
Jan 21, 2011·Physiological Reviews·Alessio Fasano
Feb 16, 2021·Frontiers in Immunology·Abu Saleh Md MoinAlexandra E Butler
Aug 14, 2018·Journal of Agricultural and Food Chemistry·Niroshan SivaDil Thavarajah
Feb 4, 2014·Journal of Agricultural and Food Chemistry·Kang PanQixin Zhong
Jun 6, 2013·Journal of Agricultural and Food Chemistry·Kang PanSeung Joon Baek