Neonatal outcome following methadone exposure in utero

The Journal of Maternal-fetal Medicine
G S HagopianE E Cepeda

Abstract

To examine the relationship between maternal methadone exposure and neonatal head circumference and abstinence syndrome, we examined the records of 172 opiate-addicted gravidas enrolled in a methadone maintenance program in an urban hospital over a 2-year period. Higher doses of methadone in the third trimester were associated with increased head circumference reflecting both increased gestational duration and improved overall growth. Neonatal withdrawal was positively correlated with gestational age at delivery and race, with nonblack infants exhibiting higher neonatal abstinence scores than blacks following adjustment for maternal dose and gestational age at delivery. Selection of optimal methadone dosage is a complex problem in which the favorable neurobehavioral outcome associated with increased growth and gestational age must be weighed against the risks associated with more severe neonatal withdrawal. Our findings of improved overall fetal growth and gestational duration associated with higher methadone doses suggest that more liberal methadone dosing in pregnancy may improve long-term neonatal outcome.

Citations

Jan 9, 2007·Journal of Paediatrics and Child Health·Julee Oei, Kei Lui
Dec 10, 1999·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·E C Wang
Apr 20, 2011·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Suzanne WongUNKNOWN Society of Obstetricians and Gynaecologists of Canada
Mar 17, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S M PintoH A Mousa
Aug 2, 2008·Obstetrics and Gynecology·Eliza M F BerkleyJeffrey C Dunkelberg
Aug 30, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suzanne WongUNKNOWN Society of Obstetricians and Gynecologists of Canada
May 18, 2010·The Journal of Pediatrics·Neil S SeligmanJason K Baxter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Related Papers

BMJ : British Medical Journal
G Yamey
The Australian & New Zealand Journal of Obstetrics & Gynaecology
G K Hulse, G O'Neill
© 2021 Meta ULC. All rights reserved