Neonatal outcome of fetuses receiving intrauterine transfusion for severe hydrops complicated by Rhesus hemolytic disease

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Sabahattin AltunyurtHasan Ozkan

Abstract

To evaluate neonatal outcomes among a homogeneous group of fetuses with severe hydrops treated with intrauterine transfusion (IUT). In a prospective study at Dokuz Eylul University School of Medicine, Izmir, Turkey, outcomes were compared for 35 IUTs carried out between 2005 and 2010 in 19 pregnancies that were complicated by Rhesus D hemolytic disease with severely hydropic fetuses. There was no correlation between the number of IUTs and the duration of phototherapy or number of exchange transfusions. After delivery, 36% (7/19) of neonates tested positive in a direct Coombs test and their requirement for exchange transfusion was higher than that of neonates who tested negative. The neonatal survival rate was 73.7%. Admission to the neonatal intensive care unit was 78%, and the median duration of neonatal unit stay was 4 days (range, 1-77 days). Only 1 newborn had hearing impairment. IUT is a unique, gold standard treatment for severely hydropic fetuses. When treated optimally with IUT, fetuses with severe hydrops showed no increased risk of neurodevelopmental abnormalities. Factors affecting the survival of hydropic fetuses after IUT, and whether the number of IUTs performed affects the number of exchange transfusions required...Continue Reading

References

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Citations

Jan 22, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Susanna SainioVedran Stefanovic
Oct 24, 2015·Archives of Gynecology and Obstetrics·Dipika DekaPerumal Vanamail
Feb 29, 2020·Prenatal Diagnosis·James S Castleman, Mark D Kilby
Apr 9, 2019·Journal of Obstetrics and Gynaecology of India·Omkar PotdarPurnima R Satoskar
Aug 30, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ayşe Özge ŞavkliMehmet Aytaç Yüksel

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