Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.

PloS One
Paul D BozykMarc B Hershenson

Abstract

In bronchopulmonary dysplasia (BPD), alveolar septae are thickened with collagen and α-smooth muscle actin, transforming growth factor (TGF)-β-positive myofibroblasts. Periostin, a secreted extracellular matrix protein, is involved in TGF-β-mediated fibrosis and myofibroblast differentiation. We hypothesized that periostin expression is required for hypoalveolarization and interstitial fibrosis in hyperoxia-exposed neonatal mice, an animal model for this disease. We also examined periostin expression in neonatal lung mesenchymal stromal cells and lung tissue of hyperoxia-exposed neonatal mice and human infants with BPD. Two-to-three day-old wild-type and periostin null mice were exposed to air or 75% oxygen for 14 days. Mesenchymal stromal cells were isolated from tracheal aspirates of premature infants. Hyperoxic exposure of neonatal mice increased alveolar wall periostin expression, particularly in areas of interstitial thickening. Periostin co-localized with α-smooth muscle actin, suggesting synthesis by myofibroblasts. A similar pattern was found in lung sections of infants dying of BPD. Unlike wild-type mice, hyperoxia-exposed periostin null mice did not show larger air spaces or α-smooth muscle-positive myofibroblasts. Co...Continue Reading

References

Jan 1, 1977·Annual Review of Physiology·L B Strang
Dec 21, 1977·Biochimica Et Biophysica Acta·V Oldenborg, L M Van Golde
Jul 1, 1997·Pediatric Pulmonology·P TotiT A Seemayer
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Noben-TrauthW E Paul
Aug 5, 1998·The American Journal of Physiology·B B WarnerJ R Wispé
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Riitta Kaarteenaho-WiikPaavo Pääkkö
Apr 2, 2003·Seminars in Neonatology : SN·Jacqueline J Coalson
Apr 20, 2004·The Journal of Pathology·Riitta Kaarteenaho-WiikYlermi Soini
Aug 31, 2004·American Journal of Respiratory Cell and Molecular Biology·Alfin G VicencioJack A Elias
Jun 11, 2005·American Journal of Respiratory and Critical Care Medicine·Faruqa LadhaBernard Thébaud
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Go TakayamaKenji Izuhara
Sep 27, 2006·Immunogenetics·Gregory S WhiteheadDavid A Schwartz
Mar 3, 2007·American Journal of Respiratory and Critical Care Medicine·Kenneth T HennrickMarc B Hershenson
May 10, 2007·Physiological Genomics·Daniel R ProwsTodd G Nick
May 3, 2008·The Journal of Biological Chemistry·Daniel L CoutuJacques Galipeau
Jan 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Veniamin RatnerVadim S Ten
Jun 23, 2009·American Journal of Respiratory Cell and Molecular Biology·Shu WuEduardo Bancalari
Sep 15, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Umadevi SajjanMarc B Hershenson
Jan 30, 2010·BMC Evolutionary Biology·Sebastian Hoersch, Miguel A Andrade-Navarro
Feb 26, 2010·The Journal of Biological Chemistry·Takumi MaruhashiAkira Kudo
Mar 2, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Antonia P PopovaMarc B Hershenson
Dec 24, 2010·The European Respiratory Journal·M OkamotoH Aizawa
Jul 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy S BlackwellLawrence S Prince
Nov 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna HogmalmKristina Bry

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Citations

Oct 23, 2013·Cellular and Molecular Life Sciences : CMLS·Simon J ConwayAkira Kudo
Mar 29, 2014·American Journal of Respiratory Cell and Molecular Biology·Hataya K PoonyagariyagornEnid R Neptune
Jan 22, 2013·Journal of Cell Communication and Signaling·Antonia P Popova
Mar 22, 2014·PloS One·Tracy NanceStephen B Montgomery
Oct 5, 2013·Expert Review of Respiratory Medicine·Rodney D BrittY S Prakash
Dec 4, 2015·Developmental Biology·Kelsey BranchfieldXin Sun
Jan 19, 2016·Frontiers in Medicine·Ivana Mižíková, Rory E Morty
Jun 1, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Shawn K AhlfeldSimon J Conway
Mar 19, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Stephen E McGowan
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Vineet Bhandari
Mar 13, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennifer J P Collins, Bernard Thébaud
Sep 18, 2012·Cell Adhesion & Migration·Christopher G ElliottDouglas W Hamilton
Jan 13, 2016·American Journal of Respiratory and Critical Care Medicine·Kenji IzuharaJoseph R Arron
Dec 3, 2016·American Journal of Respiratory and Critical Care Medicine·Shawn K AhlfeldBrenda B Poindexter
Feb 28, 2017·Journal of Pharmacological Sciences·Shinji TakaiDenan Jin
Jul 28, 2017·PloS One·Jennifer A SchwanekampJeffery D Molkentin
Nov 1, 2017·Journal of Cell Communication and Signaling·Akira Kudo, Isao Kii
Feb 9, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Satoshi NunomuraKenji Izuhara
Sep 10, 2017·Cellular and Molecular Life Sciences : CMLS·Isao Kii, Harumi Ito
Sep 18, 2017·Cellular and Molecular Life Sciences : CMLS·David N O'Dwyer, Bethany B Moore
Jul 6, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Bernard Thébaud
Dec 19, 2018·American Journal of Respiratory Cell and Molecular Biology·Marius A MöbiusBernard Thébaud
Feb 16, 2019·American Journal of Respiratory Cell and Molecular Biology·Antonia P Popova
Jan 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shilpa Vyas-ReadLou Ann S Brown
Sep 11, 2019·American Journal of Respiratory Cell and Molecular Biology·Yasuhiro NanriKenji Izuhara
Sep 13, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Diogo M G SilvaRory E Morty
Apr 10, 2019·Allergy·Kenji IzuharaAtsushi Kawaguchi
Aug 18, 2020·Science Translational Medicine·Shanna L AshleyRobert P Dickson
Mar 19, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Leonor GouveiaJohanna Andrae
Mar 21, 2020·Cancer Research·Casimiro GerarduzziElliot Drobetsky
Mar 10, 2021·Veterinary Pathology·Lauren N AlfinoDaniel P Regan
Mar 27, 2021·Frontiers in Medicine·Luciano AmarelleLeonel Malacrida
Jul 6, 2014·The Journal of Allergy and Clinical Immunology·J Kelley BentleyMarc B Hershenson

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Methods Mentioned

BETA
fluorescence microscopy
PCR
genotyping

Software Mentioned

NIH ImageJ

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