Neonatal phytoestrogen exposure alters oviduct mucosal immune response to pregnancy and affects preimplantation embryo development in the mouse.

Biology of Reproduction
Wendy N JeffersonCarmen J Williams

Abstract

Treatment of neonatal mice with the phytoestrogen genistein (50 mg/kg/day) results in complete female infertility caused in part by preimplantation embryo loss in the oviduct between Days 2 and 3 of pregnancy. We previously demonstrated that oviducts of genistein-treated mice are "posteriorized" as compared to control mouse oviducts because they express numerous genes normally restricted to posterior regions of the female reproductive tract (FRT), the cervix and vagina. We report here that neonatal genistein treatment resulted in substantial changes in oviduct expression of genes important for the FRT mucosal immune response, including immunoglobulins, antimicrobials, and chemokines. Some of the altered immune response genes were chronically altered beginning at the time of neonatal genistein treatment, indicating that these alterations were a result of the posteriorization phenotype. Other alterations in oviduct gene expression were observed only in early pregnancy, immediately after the FRT was exposed to inflammatory or antigenic stimuli from ovulation and mating. The oviduct changes affected development of the surviving embryos by increasing the rate of cleavage and decreasing the trophectoderm-to-inner cell mass cell ratio...Continue Reading

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Citations

Nov 2, 2013·Animal Reproduction Science·Faviola Pedrero-BadilloEstela Cuevas
Jun 13, 2013·Molecular Reproduction and Development·Miranda L Bernhardt, Ximena Bustamante-Marín
Jun 21, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Xiao Juan HuMing Yong Xie
Apr 22, 2017·American Journal of Reproductive Immunology : AJRI·Yotesawee SrisomboonChatsri Deachapunya
Mar 21, 2017·Research in Veterinary Science·Daniela C GarcíaMariela Roldán-Olarte
Apr 7, 2018·Environmental Health Perspectives·Shannon D WhirledgeJohn A Cidlowski

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Methods Mentioned

BETA
PCR
ELISA
dissections

Software Mentioned

GraphPad Prism
Ingenuity analysis
Imagescope
Rosetta Resolver Pathway Analysis
GraphPad

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