Neonatal respiratory mechanics and development of bronchial hyperresponsiveness in preterm infants

Early Human Development
Yvonne SnepvangersCornelis K Van der Ent

Abstract

In preterm ventilated infants, irreversible damage to the airway mucosa in the neonatal period might be related to the development of bronchial hyperresponsiveness (BHR) in subsequent years. To evaluate whether neonatal indicators of long-term respiratory morbidity, respiratory system compliance (Crs) and resistance (Rrs), were causally related to bronchial responsiveness at the age of 2 and whether these relationships were affected by other factors. Mean neonatal Crs and Rrs of the first 3 days of life were assessed using the single breath occlusion technique. Bronchial challenge tests were performed at 2 years of age. When wheezing occurred during chest auscultation or oxygen saturation decreased below 90%, the provocative concentration of methacholine was recorded. Forty-five preterm infants of <37 weeks gestation, being mechanically ventilated within 24 h after birth. Decreased neonatal Crs was related to BHR (beta per ml/kPa, 0.061; 95% confidence interval, 0.019 to 0.103; p=0.006). Correction was required for radiological gradation of respiratory distress syndrome, the maximal peak inspiratory pressure required during mechanical ventilation and postnatal corticosteroid therapy. Neonatal Rrs, gestational age and birth weig...Continue Reading

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Citations

Jan 11, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·V R KairamkondaN J Shaw
Mar 7, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Junying WangAkihiro Morikawa
Aug 15, 2009·Journal of Applied Physiology·Robert De MatteoRichard Harding
Mar 28, 2017·Medical & Biological Engineering & Computing·Barbara StankiewiczMaciej Kozarski

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