Abstract
In preterm ventilated infants, irreversible damage to the airway mucosa in the neonatal period might be related to the development of bronchial hyperresponsiveness (BHR) in subsequent years. To evaluate whether neonatal indicators of long-term respiratory morbidity, respiratory system compliance (Crs) and resistance (Rrs), were causally related to bronchial responsiveness at the age of 2 and whether these relationships were affected by other factors. Mean neonatal Crs and Rrs of the first 3 days of life were assessed using the single breath occlusion technique. Bronchial challenge tests were performed at 2 years of age. When wheezing occurred during chest auscultation or oxygen saturation decreased below 90%, the provocative concentration of methacholine was recorded. Forty-five preterm infants of <37 weeks gestation, being mechanically ventilated within 24 h after birth. Decreased neonatal Crs was related to BHR (beta per ml/kPa, 0.061; 95% confidence interval, 0.019 to 0.103; p=0.006). Correction was required for radiological gradation of respiratory distress syndrome, the maximal peak inspiratory pressure required during mechanical ventilation and postnatal corticosteroid therapy. Neonatal Rrs, gestational age and birth weig...Continue Reading
References
May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Jan 1, 1990·Pediatric Pulmonology·K N ChanM Silverman
Nov 1, 1990·The American Review of Respiratory Disease·S M StickP N Lesouëf
Dec 1, 1990·The American Review of Respiratory Disease·G L Montgomery, R S Tepper
Jan 1, 1989·Pediatric Pulmonology·M Galdès-SebaldtM Stahlman
Apr 1, 1988·The Journal of Pediatrics·A AvitalS Godfrey
Jul 1, 1987·The American Review of Respiratory Disease·E K MotoyamaR D Guthrie
Jul 1, 1987·Pediatric Pulmonology·G MorietteC Gaultier
Feb 1, 1974·The Journal of Pathology·J M Finlay-JonesR A Barter
Oct 1, 1973·Pediatric Radiology·A GiedionP Dangel
Mar 1, 1995·The European Respiratory Journal·N M WilsonM Silverman
Mar 1, 1996·Thorax·A B SprikkelmanW M van Aalderen
Jul 1, 1996·Acta Paediatrica·A GreenoughB Yüksel
Nov 1, 1995·Pediatric Pulmonology·S ParatC Gaultier
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·A S PelkonenM Turpeinen
Sep 25, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H MochizukiA Morikawa
Dec 22, 1999·The European Respiratory Journal·S C YongR A Primhak
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C SpringerA Avital
Apr 20, 2001·The European Respiratory Journal·M GappaUNKNOWN ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Soci
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Ola Hjalmarson, Kenneth Sandberg
May 25, 2002·Intensive Care Medicine·R HentschelG Jorch
May 27, 2003·The European Respiratory Journal·W A DikL J I Zimmermann
Citations
Jan 11, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·V R KairamkondaN J Shaw
Mar 7, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Junying WangAkihiro Morikawa
Feb 24, 2006·Pediatric Pulmonology·Monika GappaJanet Stocks
Sep 26, 2006·Pediatric Pulmonology·N KatierC K van der Ent
Aug 15, 2009·Journal of Applied Physiology·Robert De MatteoRichard Harding
Mar 28, 2017·Medical & Biological Engineering & Computing·Barbara StankiewiczMaciej Kozarski