Neonatal respiratory morbidity following exposure to chorioamnionitis

BMC Pediatrics
Amy MetcalfeK S Joseph

Abstract

There are conflicting results in the literature on the impact of chorioamnionitis on neonatal respiratory morbidities. However, most studies are based on small clinical samples and fail to account for the competing risk of perinatal death. This study aimed to determine whether chorioamnionitis affects the incidence of respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) after accounting for the increased risk of death. Retrospective cohort study using linked birth and infant death registration and hospitalization records from Washington State between 2002 and 2011 (n = 763,671 singleton infants and n = 56,537 singleton preterm infants). Logistic regression models based on the traditional and fetuses-at-risk approaches were used to model two composite outcomes namely RDS and perinatal death and BPD and perinatal death. Confounders adjusted for in the models included maternal age, race, diabetes, hypertension, antenatal corticosteroids, mode of delivery and infant sex. While models using the traditional approach found a significant association only between chorioamnionitis and composite BPD and perinatal death (OR = 1.23, 95% CI: 1.01-1.50); using the fetuses-at-risk approach, there was a significant associati...Continue Reading

References

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Citations

Nov 28, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ruofan YaoKatherine R Goetzinger
Feb 22, 2018·Journal of Translational Medicine·Nicola PrincipiSusanna Esposito
Aug 6, 2020·Scientific Reports·Christopher R NitkinVenkatesh Sampath
Nov 28, 2020·The Journal of Pediatrics·Toshinori NakashimaUNKNOWN Neonatal Research Network of Japan
Feb 25, 2021·Obstetrical & Gynecological Survey·Emma S RyanSarah Dotters-Katz

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