Neonatal Resveratrol and Nicotinamide Riboside Supplementations Sex-Dependently Affect Beige Transcriptional Programming of Preadipocytes in Mouse Adipose Tissue

Frontiers in Physiology
Madhu Asnani-KishnaniJoan Ribot

Abstract

Nutritional programming of the thermogenic and fuel oxidation capacity of white adipose tissue (WAT) through dietary interventions in early life is a potential strategy to enhance future metabolic health. We previously showed that mild neonatal supplementations with the polyphenol resveratrol (RSV) and the vitamin B3 form nicotinamide riboside (NR) have sex-dependent, long-term effects on the thermogenic/oxidative phenotype of WAT of mice in adulthood, enhancing this phenotype selectively in male animals. Here, we tested the hypothesis that these dietary interventions may impact the commitment of progenitor cells resident in the developing WAT toward brown-like (beige) adipogenesis. NMRI mice received orally from postnatal day 2-20 (P2-20) a mild dose of RSV or NR, in independent experiments; control littermates received the vehicle. Sex-separated primary cultures were established at P35 from the stromovascular fraction of inguinal WAT (iWAT) and of brown adipose tissue (BAT). Expression of genes related to thermogenesis and oxidative metabolism was assessed in the differentiated cultures, and in vivo in the iWAT depot of young (P35) animals. Neonatal RSV and NR treatments had little impact on the animals' growth during early p...Continue Reading

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Citations

Sep 21, 2019·Organic & Biomolecular Chemistry·M V MakarovM E Migaud
Nov 2, 2019·International Journal of Molecular Sciences·Martina La SpinaLucia Biasutto
Aug 1, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Leonardo A Rodriguez-LópezArmando R Tovar

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Methods Mentioned

BETA
electrophoresis
PCR
dissection

Software Mentioned

SPSS Statistics
StepOne

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