PMID: 9419772Jul 1, 1994Paper

Neonatal salvage by week's gestation in pregnancies complicated by HELLP syndrome

Journal of the Society for Gynecologic Investigation
E F MagannJ N Martin

Abstract

For clinical management and counseling purposes, we determined the neonatal salvage by weeks' gestation and birth weight of pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets). All patients who delivered with a diagnosis of HELLP syndrome between January 1, 1980 and December 31, 1991 at a single tertiary care medical center were evaluated for neonatal outcome and survival. The syndrome was diagnosed in the presence of severe preeclampsia/eclampsia accompanied by laboratory evidence of hemolysis, hepatic dysfunction, and thrombocytopenia. During the study interval, 58,670 live-born deliveries occurred, of which 527 (0.11%) had HELLP syndrome. In this population, 143 patients delivered fetuses at less than 30 weeks' gestational age. Based upon gestational age intervals, neonatal salvage was 0% at 23 weeks in 13 deliveries, 17% (intact salvage 8.5%) at 24 weeks, 31% (intact salvage 15%) at 25 weeks, 75% (intact salvage 65%) at 26 weeks, 80% (intact salvage 70%) at 27 weeks, and 83% at 28 and 29 weeks (intact salvage 70 and 76%). Based on birth weight intervals, neonatal salvage was 0% at less than 600 g, 34% at 600-700 g (intact salvage 17%), 69% at 700-800 g (intact salvage 53%), and 8...Continue Reading

References

Jun 1, 1980·Archives of Disease in Childhood·V Y Yu, E Hollingsworth
Nov 25, 1993·The New England Journal of Medicine·M C AllenA E Dusman
May 1, 1993·The Australian & New Zealand Journal of Obstetrics & Gynaecology·E F MagannJ N Martin

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Citations

Mar 5, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P Vigil-De Gracia, E García-Cáceres
Jan 9, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P Vigil-De Gracia
May 26, 2004·Gynecologic and Obstetric Investigation·Halil AslanAltan Cebeci
Oct 5, 2007·Gynäkologisch-geburtshilfliche Rundschau·C Bartz, W Rath
Feb 8, 2008·Digestive Diseases and Sciences·Iryna S Hepburn, Robert R Schade
Apr 25, 2006·American Journal of Obstetrics and Gynecology·James N MartinChristian M Briery

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