Neonatal seizures in preterm newborns: A predictive model for outcome

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Francesco PisaniElena Pavlidis

Abstract

With a reported prevalence of 22.2%, seizures in preterm newborns represent an emergent challenge, because they are often related to adverse outcome. The electroclinical features of preterm infants with neonatal seizures were evaluated in order to predict outcome. From 154 newborns with video-EEG confirmed neonatal seizures admitted to Parma University Hospital between January 1999 and December 2012, we collected 76 preterm newborns with neonatal seizures. Outcome was assessed at least at one year. Student t-test for unpaired data was used to compare means of continuous variables. We applied the χ(2) test to compare nominal data between preterm newborns with favorable versus adverse outcome, and between those with seizures versus those with status epilepticus. Then we determined the independent risk factors for adverse outcome with multivariate logistic regression analysis. Birth weight, Apgar at 1st minute, neurologic examination, EEG, US brain scans and the presence of neonatal status epilepticus were different between preterm newborns with favorable and adverse outcome (p ≤ .049). Furthermore, birth weight, seizure onset, neurologic examination and EEG were different between the group with or without status (p ≤ .031). None ...Continue Reading

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Apr 19, 2016·Pediatric Research·Rhodri O LloydGeraldine B Boylan
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Oct 23, 2020·Neuropediatrics·Osama TanousRaed Salim
Jan 23, 2019·Neonatology·Irina MeledinEilon Shany

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European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Elena PavlidisFrancesco Pisani
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