Abstract
Few studies have examined when children with neonatal sinovenous thrombosis come to medical attention, risk factors associated with time of presentation, what clinical presentations are more likely to occur early or late, or whether the timing of presentation or severity of clinical presentation correlate with radiographic findings. Chi-square and Fisher's exact tests were used to explore associations in a cohort of 59 neonates with sinovenous thrombosis. Most (66%) came to medical attention within 48 hours of birth (defined as early presentation). Most (88%) had multiple comorbidities. Respiratory distress (P = 0.005), hypoxia (P = 0.02), poor tone (P = 0.05), fetal distress (P < 0.001), preterm delivery (P = 0.044), and low Apgar score (P = 0.018) were associated with early presentation. Infant dehydration was associated with late presentation (P < 0.001). Time of presentation was not associated with radiographic severity. Presentation with difficult-to-control seizures was marginally associated with hemorrhage (P = 0.096) but no other measure of radiographic severity. Neonates with sinovenous thrombosis often present within 48 hours, with multiple comorbidities and presenting signs, some of which are associated with time of ...Continue Reading
References
Jul 1, 1992·Annals of Neurology·M J RivkinE M Kaye
May 1, 1989·Pediatric Neurology·M I ShevellJ L Montes
Dec 1, 1988·Annals of Neurology·T Z BaramC B McArdle
Jul 1, 1987·Pediatric Neurology·Y KonishiY Ishii
Feb 24, 2001·Clinical Pediatrics·B M Gebara, K O Everett
Aug 11, 2001·The New England Journal of Medicine·G deVeberUNKNOWN Canadian Pediatric Ischemic Stroke Study Group
Aug 21, 2001·Journal of Child Neurology·K S CarvalhoB P Garg
Oct 6, 2001·Pediatric Neurology·R W HuntA Lam
Aug 15, 2002·Neurology·Yvonne W WuD M Ferriero
Aug 27, 2003·Circulation·Christine HellerUNKNOWN Childhood Stroke Study Group
Feb 9, 2005·Brain : a Journal of Neurology·G SébireF J Kirkham
Mar 15, 2006·Archives of Neurology·Karima C FitzgeraldMeredith R Golomb
Apr 26, 2006·Neurology·Meredith R GolombBhuwan P Garg
Jul 5, 2007·Journal of Child Neurology·Meredith R GolombLinda S Williams
Citations
Dec 10, 2009·Current Opinion in Pediatrics·Char Witmer, Rebecca Ichord
Jun 23, 2011·Journal of Child Neurology·Karina J KersbergenLinda S de Vries
Jun 2, 2011·Journal of Child Neurology·Mahendranath D MoharirGabrielle A Deveber
Jan 7, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A OulmaatiA Bouharrou
Oct 22, 2013·Pediatric Neurology·Alex M MortimerShelley A Renowden
Aug 25, 2009·Seminars in Fetal & Neonatal Medicine·Luca A RamenghiFabio Mosca
Mar 14, 2016·Journal of Neuroradiology. Journal De Neuroradiologie·Valentina LolliGustavo Soto Ares
Sep 27, 2015·Neurobiology of Disease·Henrik HagbergFloris Groenendaal
Jun 25, 2010·Developmental Medicine and Child Neurology·Sebastian GruntUNKNOWN Swiss Neuropaediatric Stroke Registry
Jan 17, 2014·Acta Paediatrica·N E van der AaL S de Vries
Dec 8, 2015·Hematology·Sarah H O'Brien
Feb 20, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ömer BektaşGülhis Deda
Dec 17, 2014·Lupus·M P De CarolisS De Carolis
Jul 28, 2015·Korean journal of pediatrics·Sadık YurttutanUgur Dilmen
Jun 5, 2010·Stroke; a Journal of Cerebral Circulation·Florieke J BerfeloTimo R de Haan
Jun 23, 2009·Stroke; a Journal of Cerebral Circulation·Karina J KersbergenFloris Groenendaal
Apr 27, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria Garrido-BarberoAlfredo Garcia-Alix
Jan 29, 2021·Developmental Medicine and Child Neurology·Anna-Lisa SorgMark Dzietko
Mar 19, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Joel FlussStéphane Chabrier
Jun 15, 2021·Pediatric Neurology·Isabella HermanDavut Pehlivan
Aug 11, 2010·Pediatrics·Janet Y K YangBosco A Paes