Neonatal T cells in an adult lung environment are competent to resolve Pneumocystis carinii pneumonia

The Journal of Immunology : Official Journal of the American Association of Immunologists
Mahboob H Qureshi, Beth A Garvy

Abstract

Initiation of the pulmonary inflammatory response to Pneumocystis carinii is delayed by 3 wk in mice infected as neonates compared with adults. There was no difference in the proliferative response of draining lymph node T cells from mice infected as neonates compared with adults when stimulated in vitro with either Con A or anti-CD3 mAB: However, TNF-alpha and IFN-gamma mRNA expression in the lungs of P. carinii-infected neonates was significantly lower than in adults indicating a lack of appropriate activation signaling in the local environment. This may have been due to active suppression because TGF-beta mRNA expression was significantly elevated in neonatal lungs compared with adults. To determine whether T cells from 10-day-old mice would effect resolution of P. carinii if harbored in an adult lung environment, cells were adoptively transferred to SCID mice with established P. carinii infections. There was no difference in the kinetics of T cell migration into the lungs or of clearance of P. carinii organisms when SCID mice were reconstituted with splenocytes from young mice as compared with adult mice. Furthermore, splenocytes from young mice stimulated both TNF-alpha and IFN-gamma mRNA expression to levels that were sim...Continue Reading

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Citations

Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahboob H QureshiBeth A Garvy
Dec 1, 2017·Frontiers in Immunology·Laura Lambert, Fiona J Culley
Nov 9, 2017·Pediatric Pulmonology·Katherine M EichingerKerry M Empey
Nov 20, 2002·The Journal of Experimental Medicine·Fiona J CulleyPeter J M Openshaw
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahboob H QureshiBeth A Garvy
Sep 22, 2016·Mucosal Immunology·N TorowE S Gollwitzer
Mar 9, 2018·Frontiers in Immunology·Wendy FonsecaCatherine Ptaschinski
Jul 2, 2019·Journal of Leukocyte Biology·Adam J FikeAlison J Carey
Jul 2, 2004·Nature Reviews. Immunology·Becky AdkinsStuart Marshall-Clarke
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahboob H QureshiBeth A Garvy
Oct 4, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zvezdana Vuk-PavlovicAndrew H Limper
Jul 2, 2010·Endocrinology·Oliver R OakleyChemyong Ko

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