PMID: 9531342Apr 8, 1998Paper

Neonatal thrombocytopenia: incidence and characterization of maternal antiplatelet antibodies by MAIPA assay

British Journal of Haematology
P de MoerlooseP Hohfeld

Abstract

Neonatal thrombocytopenia (NNT) which is frequent in distressed newborns was uncommon in a non-selected population of neonates. The aim of this prospective study was to determine the frequency of NNT and, in confirmed NNT, to search for maternal antiplatelet antibodies with a monoclonal antibody-specific immobilization of platelet antigens (MAIPA) assay. Among the 8388 newborns studied, 40 (0.5%, 95% CI 0.3-0.6) had confirmed NNT, which was severe (platelet count < 50 x 10[9]/l) in 10 cases (0.12%, 95% CI 0.05-0.20). Antiplatelet antibodies were detected in 10/31 studied mothers of thrombocytopenic newborns (32.3%): they were alloantibodies in five cases and autoantibodies in five other cases. Among these 10 newborns, seven had severe thrombocytopenia and four had bleeding complications. As controls, antiplatelet antibodies were also searched for in mothers of non-thrombocytopenic newborns: antiplatelet antibodies were present in 8.5% (95% CI 5.9-11.7) of thrombocytopenic mothers (n = 400) and 3.2% (95% CI 0.7-9.0) of non-thrombocytopenic mothers (n = 95). The difference was significant between the control groups and the group of mothers of thrombocytopenic newborns. In conclusion, our data indicate that an immune origin is fre...Continue Reading

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Citations

Feb 5, 1999·Obstetrics and Gynecology·F BoehlenP de Moerloose
Jan 15, 2000·Obstetrics and Gynecology·F BoehlenP de Moerloose
Mar 11, 2000·Obstetrics and Gynecology·S SainioR Kekomäki
Nov 16, 2005·Clinical Obstetrics and Gynecology·Cynthia Gyamfi, Keith A Eddleman
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May 24, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jens Kjeldsen-KraghBjørn Skogen
Nov 6, 2007·Blood Reviews·James B Bussel, Andrea Primiani
Oct 16, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Eline S A van den Akker, Dick Oepkes
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Apr 25, 2009·British Journal of Haematology·Matthias Ballmaier, Manuela Germeshausen
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