PMID: 11320049Apr 26, 2001Paper

Neonatal thrombocytosis resulting from the maternal use of non-narcotic antischizophrenic drugs during pregnancy

Archives of Disease in Childhood. Fetal and Neonatal Edition
Y NakoA Morikawa

Abstract

Neonatal thrombocytosis can result from maternal narcotic drug abuse. The case of a male infant is reported who was born to a woman with schizophrenia treated with non-narcotic psychotropic drugs during pregnancy; he developed severe prolonged thrombocytosis. The platelet count reached 1310 x 10(9)/l on day 15. This thrombocytosis persisted for three months. The patient was treated with dipyridamole. A bone marrow aspirate showed normal myeloid and erythroid precursors with an increased number of megakaryocytes. Plasma concentrations of interleukin 6 and thrombopoietin were suppressed. No obvious complications from the thrombocytosis occurred, and the platelet count fell to within the upper limit of normal after 3 months of age. This case indicates that thrombocytosis may occur in infants born to mothers treated with non-narcotic psychopharmaceutical drugs during pregnancy. The thrombocytosis in this case may have been induced by factors other than interleukin 6 or thrombopoietin.

References

Mar 1, 1989·Archives of Disease in Childhood·H M Chambers, R R Haslam
Mar 1, 1982·The Journal of Pediatrics·Y BursteinC M Peterson
Jul 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·Y BursteinC M Peterson
Oct 1, 1994·The American Journal of Medicine·A TefferiP R Greipp
Jan 1, 1994·Klinische Pädiatrie·L Hanssler, C Roll
Oct 1, 1993·Acta Paediatrica·I YoshidaF Yamashita
Jan 1, 1993·Archives of Disease in Childhood·A J Vora, J S Lilleyman
Jan 1, 1995·Seminars in Thrombosis and Hemostasis·A H Sutor
Nov 1, 1996·Journal of Pediatric Hematology/oncology·G KapoorL C Yu
Sep 10, 1998·The New England Journal of Medicine·K Kaushansky
Jan 12, 1999·Mediators of Inflammation·A SarandakouI Phocas
Oct 16, 1999·The Journal of Laboratory and Clinical Medicine·H C HsuS Y Wang
Apr 29, 2000·Current Opinion in Hematology·W VerbeekG Brittinger

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Citations

Feb 7, 2002·Pharmacoepidemiology and Drug Safety
Mar 16, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cornelia Feiterna-SperlingMichael Obladen
Oct 6, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Micky OsovskyPaul Merlob
Dec 12, 2018·The Annals of Pharmacotherapy·Quyen T Vo, Dennis F Thompson
Jun 13, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Irma ConvertinoMarco Tuccori

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