Neonatal tolerance of H-2 alloantigens. I. I region modulation of tolerance potential of K and D antigens

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J W Streilein, J Klein

Abstract

By utilizing H-2 congenic strains of mice and appropriate recombinants, it has been possible to determine that Class I alloantigens (of K and D region genes) function poorly as tolerogens when inoculated into neonatal recipients. Alternatively, Class II alloantigens (encoded by I region genes) are excellent tolerogens. Moreover, Class I alloantigens are converted to good tolerogens when conjoined in the tolerizing inoculum with Class II alloantigens. The I subregions in which genes reside that mediate this tolerance-promoting effect are IJ and/or IE. It is suggested that elicitation of a suppressor mechanism, perhaps related to IJ region alloantigens, is responsible.

Citations

Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D FaustmanJ Davie
Jan 1, 1979·Immunological Reviews·M Hasek, J Chutná
Jan 1, 1979·Immunological Reviews·J W Streilein
Feb 1, 1981·Immunology Today·M I GreeneJ S Bromberg
Jan 1, 1982·Annals of the New York Academy of Sciences·J W StreileinP Strome
Mar 1, 1982·European Journal of Immunology·P J Wood, J W Streilein

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