Neonatal tolerance of H-2 alloantigens. II. I region dependence of tolerance expressed to K and D antigens

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J W Streilein

Abstract

Third-party skin allografts were employed to test the specificity of transplantation tolerance achieved by neonatal inoculation of cells bearing H-2 alloantigens. Tolerant animals rejected with normal vigour third-party grafts expressing strong Class I alloantigens foreign to the host and to the donor of the tolerance-conferring inoculum. However, these animals rejected with exceptional vigour third-party grafts expressing weak Class II alloantigens plus the tolerated Class I alloantigen; even third-party grafts comprised of the host's own Class II antigens in conjunction with the tolerated Class I alloantigen were acutely rejected. It is proposed, but there is no direct evidence to prove, that rejection of these third-party grafts is mediated by killer T cells directed at the tolerated Class I alloantigens and that these cells are activated by the presentation of the putative tolerogen in an inappropriate I region context. Inconsistency of these data with a clonal deletion mechanism is discussed.

References

Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR

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Citations

Jan 1, 1982·Annals of the New York Academy of Sciences·J W StreileinP Strome
Apr 20, 2016·Frontiers in Immunology·Hua PanMauricette Michallet
Mar 19, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Frederike BemelmanIneke ten Berge
Apr 1, 1994·Acta Physiologica Scandinavica·G MagnussonB Saltin
Aug 1, 1982·Journal of Microscopy·D M Harvey

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