Neonatal transection alters the percentage of substance-P-positive trigeminal ganglion cells that contribute axons to the regenerate infraorbital nerve.

Somatosensory & Motor Research
H L EnfiejianR W Rhoades

Abstract

Neonatal transection results in a marked reduction of the number of trigeminal (V) ganglion cells that contribute axons to the regenerate infraorbital nerve (ION; Jacquin and Rhoades, 1985; Chiaia et al., 1987). Such lesions also produce a profound deafferentation of the V brain stem complex that appears to spare the innervation of layers I and II of subnucleus caudalis (SpC) by substance-P-positive (SP-positive) primary afferents (Jacquin and Rhoades, 1985; Rhoades et al., 1988). In the present study, we combined retrograde tracing with immunocytochemistry to determine whether neonatal transection of the ION alters the percentage of SP-positive V ganglion cells that contribute axons to this V branch upon regeneration. In V ganglia ipsilateral to the intact ION (n = 8), 11.6% +/- 3.2% of the cells labeled after application of true blue (TB) to the ION were also SP-positive. In ganglia ipsilateral to the neonatally damaged nerve (n = 8), 18.6% +/- 4.7% of the cells labeled after application of TB to the regenerate ION were also SP-positive (p less than 0.001). We also compared the SP content of intact ganglia (n = 10) with that of ganglia ipsilateral to the damaged nerve (n = 10) by means of radioimmunoassay. The normal V gangli...Continue Reading

References

Jan 1, 1978·Annual Review of Neuroscience·P H Patterson
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
May 1, 1979·The Journal of Comparative Neurology·M DevorP D Wall
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J E Adler, I B Black
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R A StoneT N Wiesel
Oct 15, 1986·The Journal of Comparative Neurology·B L Munger, F L Rice
Apr 1, 1986·Experimental Neurology·D D HeathC E Hulsebosch
May 1, 1985·The Journal of Comparative Neurology·M F Jacquin, R W Rhoades
Jan 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·P M Waite, B G Cragg
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J A Kessler, I B Black
Jan 1, 1980·Neuroscience·M Del Fiacco, A C Cuello
Jul 29, 1982·Brain Research·J P SchwartzE M Johnson
Oct 1, 1982·The Journal of Comparative Neurology·V M PickelR J Miller
Nov 20, 1984·The Journal of Comparative Neurology·K M RichE M Johnson
Sep 10, 1984·The Journal of Comparative Neurology·S N LawsonB H Anderton
Feb 1, 1983·Journal of Neurocytology·A RambourgA Beaudet
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y A BardeH Thoenen
Jul 1, 1941·Journal of Neurology and Psychiatry·G WeddellE Gutmann
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C S Ayer-LeLievre, A Seiger

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Citations

Jan 1, 1991·The European Journal of Neuroscience·Peter Shortland, Maria Fitzgerald
Feb 6, 1995·The Journal of Comparative Neurology·F A WhiteR W Rhoades
May 8, 1993·The Journal of Comparative Neurology·F A WhiteR W Rhoades
Apr 13, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J R Zuniga

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