Neonatal transplantation tolerance is associated with a systemic reduction in memory cells, altered chimeric cell phenotype, and modified eicosanoid and cytokine production

Transplantation
P RuizJ W Streilein

Abstract

Certain B10 background mice are resistant to tolerance induction following a neonatal inoculation of semiallogeneic class I/II MHC-disparate cells despite early thymic clonal deletion of alloreactive cells. The emergence of memory T cells and persistence of particular chimeric cells in the thymus has an association with this resistance. In these studies, we utilized a hemisplenectomy technique to examine systemic cell populations of adult Bl0.S (H2s, H2E-) mice that received (Bl0.S x B10.A)F1 cells at birth and before and following application (and rejection or acceptance) of Bl0.A (H2k/d, H2E+) skin grafts. Prior to skin graft challenge, tolerant mice had reduced splenic levels of memory (CD45hi, PgP-1hi, Mel-14neg) T cells as compared with the rejecting recipients and following B10.A graft challenge, the nontolerant mice showed a further increase in these cells. Elevated pretransplant levels of donor H2Kk+ cells coexpressing B220, CD11b, or CD3 were seen in the tolerant mice. Following skin grafting, splenic chimerism was reduced with differing chimeric cell phenotypes between the tolerant and nontolerant mice. In vitro production of PGE2 in a MLC was delayed in the tolerant mice with minimal production of IL-2 and IL-4. Nont...Continue Reading

References

Sep 1, 1992·Transplantation·P RuizA Viciana
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Jan 1, 1993·Advances in Immunology·C R Mackay

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Citations

Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·M E BerensS W Coons
Oct 17, 2013·International Reviews of Immunology·Paulo Ney Aguiar MartinsJames F Markmann
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Fadi G Lakkis, Mohamed H Sayegh

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