PMID: 7019374Apr 1, 1981Paper

Neonatal treatment with low doses of anti-idiotypic antibody leads to the expression of a silent clone

The Journal of Experimental Medicine
J HiernauxP J Baker

Abstract

BALB/c mice immunized with bacterial levan (BL) produce an immune response that fails to generate antibody expressing the idiotype (Id) of the beta (2 leads to 6) fructosan-binding myeloma protein ABPC 48 (A48). Pretreatment of newborn BALB/c mice (at 1 d of age) with 0.01-10 microgram of affinity purified BALB/c anti-A48 Id antibody followed by immunization with BL 1-2 mo later produces an anti-BL response that expresses the A48 Id. This shows that A48 Id+ anti-BL clones belong to a normally silent fraction of the anti-BL repertoire. The activation of A48 Id+ anti-BL clones anti-A48 Id antibody is specific because the pretreatment of newborn mice with anti-MOPC 384 Id antibody, followed by immunization with BL, does not lead to its activation. Moreover, pretreatment of mice with anti-A48 Id antibody does not alter the MOPC 460 Id+ component of the anti-TNP response. It is also important to note that the activation of the A48 Id+ clone in pretreated mice requires subsequent immunization with BL.

References

Nov 1, 1975·The Journal of Experimental Medicine·E Trenkner, R Riblet
Jul 11, 1975·The Journal of Experimental Medicine·R LiebermanM Vrana
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Jan 1, 1980·Immunological Reviews·G KelsoeK Rajewsky
Oct 1, 1975·European Journal of Immunology·K Eichmann, K Rajewsky
Jan 1, 1964·The Journal of Experimental Medicine·T TSUMITA, M OHASHI

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Citations

Jan 1, 1986·Springer Seminars in Immunopathology·H H Shen, R J Winchester
May 1, 1994·Applied Biochemistry and Biotechnology·P G Seferian, L S Rodkey
Feb 1, 1987·International Journal for Parasitology·J F Williams
Aug 1, 1989·Immunology Letters·R J De Boer
Mar 25, 2004·Trends in Immunology·Hilmar LemkeHans Lange
Jul 10, 2003·Vaccine·Hilmar LemkeHans Lange
Oct 16, 1999·Scandinavian Journal of Immunology·H Lemke, H Lange
Jan 9, 1992·The New England Journal of Medicine·J M Dwyer
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H ZaghouaniC Bona
Nov 1, 1981·The Journal of Experimental Medicine·Y N LiuJ L Schulman
Apr 1, 1983·The Journal of Experimental Medicine·K A Denis, N R Klinman
Jul 1, 1983·The Journal of Experimental Medicine·M A ThompsonM P Cancro
Sep 1, 1983·The Journal of Experimental Medicine·P Legrain, G Buttin
Nov 1, 1983·The Journal of Experimental Medicine·R L RileyN R Klinman
Nov 1, 1985·The Journal of Experimental Medicine·B G Froscher, N R Klinman
Jan 1, 1996·Microbiology and Immunology·M Lin, E M Zhou
Apr 1, 1994·Acta Paediatrica Japonica; Overseas Edition·L A HansonE Telemo
Jan 1, 2009·Immunotherapy·Paula Ordonhez RigatoMaria Notomi Sato
Feb 15, 2012·Advances in Nutrition·Amanda C Palmer
Jan 1, 1986·International Reviews of Immunology·R C Kennedy, G R Dreesman
Jul 9, 1993·International Journal of Cancer. Journal International Du Cancer·J L BashfordM R Price
Apr 1, 1982·Immunology Today·J Urbain, C Wuilmart
Sep 1, 1990·Clinical Immunology and Immunopathology·R Q Warren, K Y Tsang
Aug 1, 1989·Immunological Reviews·C Victor-KobrinC Bona
Feb 1, 1987·Scandinavian Journal of Immunology·C Manzo, A Nisonoff
Apr 1, 1986·Immunological Reviews·F G UytdeHaagA D Osterhaus
Apr 7, 1991·Journal of Theoretical Biology·R J de Boer, A S Perelson
Jun 1, 1984·Immunological Reviews·C A BonaL J Rubinstein
Sep 1, 1990·European Journal of Immunology·R F Van VollenhovenG W Siskind
Jun 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·Y VanderbeekenG Delespesse
Jan 1, 1997·Nutrition Reviews·L A HansonE Telemo
Jun 2, 2020·Frontiers in Immunology·Angelina MimounSébastien Lacroix-Desmazes

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