Neonatal urinary uric acid/creatinine [correction of ceratinine] ratio as an additional marker of perinatal asphyxia

European Journal of Pediatrics
D BaderA Lanir

Abstract

The diagnosis and evaluation of perinatal asphyxia can be problematic and objective means of assessing its severity are lacking. To study the validity of urinary uric acid as a marker of the degree of perinatal asphyxia, the ratio of urinary uric acid to creatinine (UA/Cr) in urine specimens obtained after birth was measured in two groups of infants. Eighteen term infants with Apgar scores < or = 5 at 5 min and/or an umbilical cord blood pH < or = 7.2, and a base deficit > or = 12 meq/l were compared to 50 healthy controls. The severity of the perinatal asphyxia was determined by using an ASPHYXIA SCORE. The UA/Cr was higher in the asphyxiated group when compared to controls. (2.06 +/- 1.12, vs. 0.64 +/- 0.48; P < 0.001). Within the perinatal asphyxia group, a significant correlation was found between the UA/Cr ratio and the asphyxia score. (r = 0.86, P < 0.01). Infants with perinatal asphyxia have a significantly higher urinary UA/Cr ratio. This may be used as an indicator of the severity of perinatal asphyxia.

References

Mar 10, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·A R Butler
Jul 1, 1992·Archives of Disease in Childhood·N Marlow
Apr 1, 1992·Archives of Disease in Childhood·G A RussellR W Cooke
Jan 1, 1990·American Journal of Obstetrics and Gynecology·R J PortmanG B Merenstein
Feb 1, 1982·Pediatric Research·S Swanström, L E Bratteby

❮ Previous
Next ❯

Citations

Oct 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Pallab BasuHarendranath Das
Nov 3, 2004·Pediatric Neurology·Hasan TekgulSarenur Gokben
Aug 1, 1996·Journal of Paediatrics and Child Health·H TsukaharaM Sudo
Oct 12, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·M PrezeljM Derganc
Jul 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sahar A Fathallah-Shaykh, Monica T Cramer
Sep 8, 2010·Indian Journal of Pediatrics·Vibeke Moen, Lars Irestedt
Sep 1, 1996·European Journal of Pediatrics·H TsukaharaM Sudo
Oct 10, 2008·European Journal of Pediatrics·Pallab BasuHarendranath Das
May 2, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ioannis BellosGeorgios Daskalakis
May 16, 1998·Acta Paediatrica Japonica; Overseas Edition·M Akisü, N Kültürsay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.