Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants

The Journal of Pediatrics
M KnufF Zepp

Abstract

Because young infants are at highest risk of pertussis complications, this study assessed whether neonatal acellular pertussis (aP) vaccination could provide earlier immunity. Neonates (n = 121) were randomly assigned (1:1) to receive either aP or hepatitis B vaccine (HBV) (controls) vaccine at birth, followed by vaccination with DTaP-HBV-IPV/Hib at 2, 4 and 6 months. Immune responses were measured. Reactogenicity was assessed for 7 days after each dose. The aP birth dose was followed by few adverse events. Reactogenicity of subsequent vaccine doses did not differ between groups. Seven serious adverse events were reported from each group; none were related to the study vaccines. At 3 months of age, vaccination with aP at birth had induced significantly higher antibody responses to the 3 pertussis antigens compared with controls. At 7 months, geometric mean/concentrations of antibodies against pertussis antigens were similar in both groups, and all subjects had reached "seroprotective" antibody concentrations against diphtheria, tetanus, and poliovirus types 1, 2, and 3. Geometric mean/concentrations of antibodies to haemophilus influenzae type b (Hib) and HBV were significantly lower in the aP group. Early neonatal immunization...Continue Reading

References

May 12, 2001·Vaccine·C A Siegrist
Apr 19, 2003·BMJ : British Medical Journal·Cameron C GrantRosalie Menzies
May 7, 2005·The Pediatric Infectious Disease Journal·Kevin ForsythStanley Plotkin

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Citations

Jan 3, 2014·Indian Pediatrics·Vipin M VashishthaSailesh G Gupta
Sep 29, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A HalperinS A Halperin
Sep 29, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Flor Munoz, Janet Englund
Nov 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis A CastagniniCarol J Baker
Jul 8, 2011·Science Translational Medicine·Guzman Sanchez-Schmitz, Ofer Levy
Mar 28, 2013·BMC Infectious Diseases·Elena ChiappiniMaurizio de Martino
Apr 30, 2011·Future Microbiology·Beth A Halperin, Scott A Halperin
Oct 26, 2013·The Journal of Infectious Diseases·Kathryn M Edwards, Guy A M Berbers
Dec 14, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C Mary Healy, Carol J Baker
Feb 15, 2014·The Journal of Infectious Diseases·Jason M WarfelTod J Merkel
Sep 4, 2014·Expert Review of Vaccines·Jason M Warfel, Tod J Merkel
Jul 31, 2014·Expert Review of Vaccines·Geeta K Swamy, Sarahn M Wheeler
Jan 23, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christiane S EberhardtClaire-Anne Siegrist
Feb 16, 2013·Enfermedades infecciosas y microbiología clínica·Magda CampinsLluís Salleras-Sanmartí
Dec 12, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Moreno-PérezUNKNOWN Comité Asesor de Vacunas de la Asociación Española de Pediatría, España
Jul 6, 2010·Vaccine·Ron DaganClaire-Anne Siegrist
Mar 23, 2010·The Journal of Pediatrics·Markus KnufFred Zepp
Jan 26, 2010·Vaccine·Olivia J WhitePatrick G Holt
Jan 9, 2010·The Journal of Pediatrics·Luis A Castagnini, Flor M Munoz
Aug 13, 2008·Paediatric Respiratory Reviews·Nicholas Wood, Peter McIntyre
Aug 4, 2015·Human Vaccines & Immunotherapeutics·Hyppolite Kuekou TchidjouGiovanni Rezza
Dec 18, 2008·European Journal of Immunology·Alicia Demirjian, Ofer Levy
May 12, 2012·FEMS Immunology and Medical Microbiology·Camille Locht, Nathalie Mielcarek
Oct 16, 2014·Hospital Pediatrics·Michelle A LopezJean L Raphael
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Giovanni GabuttiGianvincenzo Zuccotti
Dec 23, 2011·Vaccine·Douglas C Hodgins, Patricia E Shewen
Nov 13, 2013·Enfermedades infecciosas y microbiología clínica·Maria-Rosa Sala-FarréJosefa Pérez-Jové
Jul 5, 2016·Frontiers in Pediatrics·Manuela Zlamy
Jul 8, 2016·Human Vaccines & Immunotherapeutics·C Mary Healy
May 1, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S EspositoUNKNOWN European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Vaccine Study Group (EVASG)
Apr 15, 2016·Journal of Medical Microbiology·Raffaella Palazzo Sero-Epidemiology Working Group
Nov 14, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nasiha SoofieShabir A Madhi
May 17, 2017·Paediatric Drugs·Kirsten P Perrett, Terry M Nolan
Sep 9, 2010·Inflammatory Bowel Diseases·Beate C SydoraRichard N Fedorak
Nov 11, 2017·Seminars in Immunopathology·Anja Saso, Beate Kampmann

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