Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation

The Journal of Pathology
Yu Leng PhuaMelissa H Little

Abstract

Congenital medullary dysplasia with obstructive nephropathy is a common congenital disorder observed in paediatric patients and represents the foremost cause of renal failure. However, the molecular processes regulating normal papillary outgrowth during the postnatal period are unclear. In this study, transcriptional profiling of the renal medulla across postnatal development revealed enrichment of non-canonical Wnt signalling, vascular development, and planar cell polarity genes, all of which may contribute to perinatal medulla/papilla maturation. These pathways were investigated in a model of papillary hypoplasia with functional obstruction, the Crim1(KST264/KST264) transgenic mouse. Postnatal elongation of the renal papilla via convergent extension was unaffected in the Crim1(KST264/KST264) hypoplastic renal papilla. In contrast, these mice displayed a disorganized papillary vascular network, tissue hypoxia, and elevated Vegfa expression. In addition, we demonstrate the involvement of accompanying systemic hypoxia arising from placental insufficiency, in appropriate papillary maturation. In conclusion, this study highlights the requirement for normal vascular development in collecting duct patterning, development of appropri...Continue Reading

References

Oct 1, 1987·British Journal of Cancer·J A RaleighD A Kelly
Jun 26, 2001·Kidney International·L A Cullen-McEwenJ F Bertram
Feb 16, 2002·Developmental Biology·Dina C MyersLilianna Solnica-Krezel
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shiying CuiSusan E Quaggin
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Silvia MarettoStefano Piccolo
Jun 14, 2003·The Journal of Biological Chemistry·Lorine WilkinsonMelissa Little
Apr 2, 2004·The Journal of Clinical Investigation·Ching-Pin ChangFeng Chen
Apr 22, 2004·Advances in Experimental Medicine and Biology·Ryozo NagaiMasahiko Kurabayashi
Sep 17, 2004·The Journal of Clinical Investigation·Juan A OliverQais Al-Awqati
Jan 27, 2006·Journal of the American Society of Nephrology : JASN·Vera EreminaSusan E Quaggin
Jun 20, 2006·Journal of Neuropathology and Experimental Neurology·Yuan RongDaniel J Brat
Aug 10, 2006·Journal of Cell Science·Toshiyasu MatsuiYoshiakira Kanai
Sep 15, 2006·Journal of the American Society of Nephrology : JASN·Stefanie WeberRemi Salomon
Nov 16, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J PennisiMelissa H Little
Apr 27, 2007·Journal of the American Society of Nephrology : JASN·Lorine WilkinsonMelissa H Little
Sep 20, 2007·Nature Reviews. Genetics·Andreas Schedl
May 7, 2008·The Journal of Cell Biology·Yueting ShangGary K Owens
Sep 13, 2008·Cell Stem Cell·Mihaela CrisanBruno Péault
Apr 3, 2009·Kidney International·Robert L ChevalierBarbara A Thornhill
May 26, 2009·Nucleic Acids Research·Jing ChenAnil G Jegga
Jun 19, 2009·American Journal of Physiology. Renal Physiology·Derek C Adams, Leif Oxburgh
Jun 23, 2009·Nature Genetics·Courtney M KarnerThomas J Carroll
Sep 19, 2009·Journal of the American Society of Nephrology : JASN·Juan A OliverQais Al-Awqati
Sep 25, 2009·Kidney International·Lorine WilkinsonMelissa H Little
Dec 25, 2009·American Journal of Physiology. Renal Physiology·Renfang SongIhor V Yosypiv
Jan 9, 2010·Journal of the American Society of Nephrology : JASN·Kirsten MadsenBoye L Jensen
Feb 6, 2010·Journal of the American Society of Nephrology : JASN·Zhao ZhangPaul Goodyer
Aug 5, 2010·International Journal of Experimental Pathology·Julie KleinJoost P Schanstra
Oct 5, 2010·Nature Chemical Biology·Curtis A ThorneEthan Lee
Jun 10, 2011·Development·Simon D HardingDuncan Davidson
Oct 4, 2011·Developmental Biology·Bree A RumballeMelissa H Little
Oct 25, 2011·Journal of the American Society of Nephrology : JASN·Jie SongBenjamin D Humphreys
Apr 19, 2012·Genesis : the Journal of Genetics and Development·Han Sheng ChiuDavid J Pennisi
Dec 12, 2012·The Journal of Pathology·Yu Leng PhuaLorine Wilkinson

❮ Previous
Next ❯

Citations

May 26, 2017·American Journal of Physiology. Renal Physiology·Elina MukherjeeSunder Sims-Lucas
Mar 7, 2019·American Journal of Physiology. Renal Physiology·Yu Leng PhuaJacqueline Ho
Jul 3, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Silvia Ferrè, Peter Igarashi

❮ Previous
Next ❯

Related Concepts

Related Papers

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
J Waldschmidt, W Hasse
The Journal of the Egyptian Medical Association
I RAGY
Health Facilities Management
D J Raysich
© 2022 Meta ULC. All rights reserved