Neonatal vitamin D status from archived dried blood spots and future risk of fractures in childhood: results from the D-tect study, a population-based case-cohort study

The American Journal of Clinical Nutrition
Mina Nicole HändelBo Abrahamsen

Abstract

Background: Whether antenatal and neonatal vitamin D status have clinical relevance in fracture prevention has not been examined extensively, although observational studies indicate that fetal life may be a sensitive period in relation to bone growth and mineralization during childhood.Objective: We examined whether 25-hydroxyvitamin D3 [25(OH)D3] concentrations in stored neonatal dried blood spot (DBS) samples are associated with pediatric fracture risk. We hypothesized that in particular, low neonatal vitamin D status may be a risk factor for fracture incidence among children.Design: In a register-based case-cohort study design, the case group was composed of 1039 individuals who were randomly selected from a total of 82,154 individuals who were born during 1989-1999 and admitted to a Danish hospital with a fracture of the forearm, wrist, scaphoid bone, clavicle, or ankle at age 6-13 y. The subcohort was composed of 1600 individuals randomly selected from all Danish children born during 1989-1999. The neonatal 25(OH)D3 concentrations in DBS samples were assessed by using highly sensitive chromatography-tandem mass spectrometry.Results: The mean ± SD 25(OH)D3 concentration for all subjects was 27.7 ± 18.9 nmol/L [median (IQR):...Continue Reading

Citations

Feb 9, 2018·American Journal of Epidemiology·Laura N Anderson, Jonathon L Maguire
Feb 9, 2018·American Journal of Epidemiology·T Sugiyama
Apr 26, 2019·Journal of the American Heart Association·Katherine A SauderDana Dabelea
May 5, 2020·Epilepsia·Ina O SpechtBerit L Heitmann
Jul 7, 2019·European Journal of Nutrition·Ina Olmer SpechtBerit L Heitmann
Jul 15, 2020·Journal of the American College of Nutrition·Mei ChungJiawen Chen
Jan 17, 2020·Acta Ophthalmologica·Ina Olmer SpechtBerit L Heitmann
Mar 20, 2021·Health Technology Assessment : HTA·Danielle E RobinsonDaniel Prieto-Alhambra
Apr 21, 2021·Annals of Clinical Biochemistry·Mads NyboKaren Andersen-Ranberg
Jul 13, 2021·Schizophrenia Research·Clara AlbiñanaJohn J McGrath

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