PMID: 6967093May 1, 1980Paper

Neoplasms of immunoregulatory T cells in clinical investigation

The Journal of Investigative Dermatology
S BroderT A Waldmann

Abstract

Normal T cells play a critical role in the regulation of humoral immune responses by acting as potentiators (helper cells) or inhibitors (suppressor cells) of the process by which B cells differentiate into immunoglobulin-secreting plasma cells. Certain diseases in which malignant T cells appear to retain an immunoregulatory function are characterized by a propensity of a lymphomatous T-cell population to infiltrate skin. Some cutaneous T-cell lymphomas, as well as some T-cell neoplasms without dermatologic involvement, provide a homogeneous supply of T lymphocytes which act as immunoregulators. The availability of neoplastic T cells with immunoregulatory properties could accelerate the serologic and biochemical analysis of the cellular control of normal immunity in man.

Citations

Oct 7, 2005·International Journal of Dermatology·Hanako OhmatsuKunihiko Tamaki
Dec 30, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Sierra M ImanseSarah M Corner

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