Neoplastic and borderline lesions of the prostate: autopsy study and epidemiological data

Pathology, Research and Practice
F SilvestriF Bassan

Abstract

Early detection and management of prostatic cancer (PC) is an important public health problem in all industrialized countries, where the relative rate of the elderly population is rapidly increasing. We examined the epidemiology of PC in the province of Trieste, Italy and studied the relationship between prostatic intraepithelial neoplasia (PIN) and PC. The average annual incidence of PC was 99.3 per 100,000 (1,739 new prostatic cancer cases were histologically diagnosed at autopsy or in surgical specimens between 1980 and 1993). In patients over 85 years of age, the incidence rate was 1,209 per 100,000 compared with 64 per 100,000 in the 55-64 age group. Trends in PC incidence rates showed a significant increase among men under 64 years of age and those between 65-74 years. Survival analysis showed that 94% of the patients with well differentiated PC were alive at 5 years, compared with 80% and 40% of those with moderately differentiated and poorly differentiated cancer, respectively. We studied 130 whole autopsy prostates, 70 radical prostatectomies with carcinoma, 63 transurethral resections or adenomectomies without cancer from patients who later developed PC and 94 transurethral resections or adenomectomies from patients w...Continue Reading

References

Oct 17, 1990·Journal of the National Cancer Institute·A L PotoskyJ W Horm
Apr 1, 1989·Journal of Clinical Pathology·P N BrawnD L Kuhl

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Citations

Oct 3, 2007·Prostate Cancer and Prostatic Diseases·G Godoy, S S Taneja
May 10, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·S Y HosseiniA Nahabedian
Feb 6, 2007·Annals of Saudi Medicine·J T AnimM E Bhatti
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·W A SakrD G Bostwick
Mar 8, 2007·Annals of Saudi Medicine·J T AnimS A Sathar

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