Neoplastic transformation induced by carbon ions

International Journal of Radiation Oncology, Biology, Physics
Daniela BettegaWilma K Weyrather

Abstract

The objective of this experiment was to compare the oncogenic potential of carbon ion beams and conventional photon beams for use in radiotherapy. The HeLa X human skin fibroblast cell line CGL1 was irradiated with carbon ions of three different energies (270, 100, and 11.4 MeV/u). Inactivation and transformation data were compared with those for 15 MeV photons. Inactivation and transformation frequencies for the 270 MeV/u carbon ions were similar to those for 15-MeV photons. The maximal relative biologic effectiveness (RBE(alpha)) values for 100MeV/u and 11.4 MeV/u carbon ions, respectively, were as follows: inactivation, 1.6 +/- 0.2 and 6.7 +/- 0.7; and transformation per surviving cell, 2.5 +/- 0.6 and 12 +/- 3. The curve for dose-transformation per cell at risk exhibited a maximum that was shifted toward lower doses at lower energies. Transformation induction per cell at risk for carbon ions in the entrance channel was comparable to that for photons, whereas for the lower energies, 100 MeV/u and 11 MeV/u, which are representative of the energies delivered to the tumor margins and volume, respectively, the probability of transformation in a single cell was greater than it was for photons. In addition, at isoeffective doses w...Continue Reading

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Citations

Aug 13, 2009·The Cancer Journal·Daniela Schulz-Ertner
Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
Jun 14, 2014·International Journal of Radiation Biology·Koichi AndoGen Kobashi
May 4, 2013·Scientific Reports·J N KavanaghG Schettino
Mar 17, 2009·Physics in Medicine and Biology·T ElsässerM Krämer
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Apr 29, 2015·Annals of the ICRP·Y YonekuraUNKNOWN International Commission on Radiological Protection
Aug 4, 2010·Journal of Radiation Research·Nobuyuki HamadaTeruki Teshima

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